L
Louise Dahl Christensen
Researcher at University of Copenhagen
Publications - 19
Citations - 1952
Louise Dahl Christensen is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Pseudomonas aeruginosa & Quorum sensing. The author has an hindex of 14, co-authored 19 publications receiving 1708 citations. Previous affiliations of Louise Dahl Christensen include Technical University of Denmark.
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Journal ArticleDOI
Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing
Tim Holm Jakobsen,Maria van Gennip,Richard Kerry Phipps,Meenakshi Sundaram Shanmugham,Louise Dahl Christensen,Morten Alhede,Mette Eline Skindersoe,Thomas Bovbjerg Rasmussen,Karlheinz Friedrich,Friedrich Uthe,Peter Østrup Jensen,Claus Moser,Kristian Fog Nielsen,Leo Eberl,Thomas Ostenfeld Larsen,David Tanner,Niels Høiby,Thomas Bjarnsholt,Michael Givskov,Michael Givskov +19 more
TL;DR: Quorum sensing (QS), a communication system used by pathogenic bacteria like Pseudomonas aeruginosa to synchronize the expression of specific genes involved in pathogenicity, is a possible drug target and ajoene, a sulfur-containing compound with potential as an antipathogenic drug is determined.
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Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm
Morten Alhede,Kasper Nørskov Kragh,Klaus Qvortrup,Marie Allesen-Holm,Maria van Gennip,Louise Dahl Christensen,Peter Østrup Jensen,Anne K. Nielsen,Matt Parsek,Daniel J. Wozniak,Søren Molin,Tim Tolker-Nielsen,Niels Høiby,Michael Givskov,Thomas Bjarnsholt,Thomas Bjarnsholt +15 more
TL;DR: The data indicate that the tolerance of both biofilms and non-attached aggregates towards antibiotics is reversible by physical disruption, and provides evidence that the antibiotic tolerance is likely to be dependent on both the physiological states of the aggregates and particular matrix components.
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Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes.
Morten Alhede,Morten Alhede,Thomas Bjarnsholt,Peter Østrup Jensen,Richard Kerry Phipps,Claus Moser,Lars Christophersen,Louise Dahl Christensen,Maria van Gennip,Matt Parsek,Niels Høiby,Thomas Bovbjerg Rasmussen,Michael Givskov +12 more
TL;DR: In vitro and in vivo analyses support a 'launch a shield' model by which rhamnolipids surround the biofilm bacteria and on contact eliminate incoming PMNs, and strengthen the view that cross-kingdom communication plays a key role in P. aeruginosa recognition and evasion of the host defence.
Journal ArticleDOI
Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes
Maria van Gennip,Louise Dahl Christensen,Morten Alhede,Richard Kerry Phipps,Peter Østrup Jensen,Lars Christophersen,Sünje Johanna Pamp,Claus Moser,Per Jensen Mikkelsen,Andrew Y. Koh,Tim Tolker-Nielsen,Gerald B. Pier,Niels Høiby,Michael Givskov,Thomas Bjarnsholt +14 more
TL;DR: The model that rhamnolipids are key protective agents of P. aeruginosa against PMNs is supported, as the experimental data showed that an inactivating mutation in the single QS‐controlled rhlA gene did not induce necrosis of PMNs in vitro and exhibited increased clearance compared with its wild‐type counterpart in vivo.
Journal ArticleDOI
Food as a Source for Quorum Sensing Inhibitors: Iberin from Horseradish Revealed as a Quorum Sensing Inhibitor of Pseudomonas aeruginosa
Tim Holm Jakobsen,Steinn Kristinn Bragason,Richard Kerry Phipps,Louise Dahl Christensen,Maria van Gennip,Morten Alhede,Mette Eline Skindersoe,Thomas Ostenfeld Larsen,Niels Høiby,Thomas Bjarnsholt,Michael Givskov +10 more
TL;DR: iberin specifically blocks expression of QS-regulated genes in P. aeruginosa, and offers a potential solution to the deficiencies associated with use of traditional antibiotics to treat infections caused by bacterial biofilms and multidrug-resistant bacteria.