Matthew Bracher-Smith

TL;DR: Genetic correlation, polygenic risk score, and copy number variation analyses indicated a shared genetic liability between psychotic experiences and major depressive disorder, schizophrenia, bipolar disorder, and neurodevelopmental disorders.

TL;DR: Many of the CNVs have profound effects on medical health and mortality, even in people who have largely escaped early neurodevelopmental outcomes, and should inform clinicians in planning and managing the medical care of CNV carriers.

TL;DR: CNVs implicated in neurodevelopmental disorders, including schizophrenia, are associated with cognitive deficits, even among unaffected individuals, which may be subtle but CNV carriers have significant disadvantages in educational attainment and ability to earn income in adult life.

TL;DR: Neurodevelopmental copy number variants appear to be associated with increases in the risk of depression in those without neurodevelopmental disorders, and no evidence was found of an association between measures of copy number variant burden and depression.

TL;DR: Performance of machine learning methods for predicting psychiatric disorders from genetics alone was highly varied and differed between schizophrenia, bipolar, autism or anorexia across 13 studies, and choices for predictor selection, hyperparameter search and validation methodology, and viewing of the test set during training were common causes of high risk of bias in analysis.