M
Matthew D.W. Piper
Researcher at Monash University
Publications - 91
Citations - 8992
Matthew D.W. Piper is an academic researcher from Monash University. The author has contributed to research in topics: Biology & Drosophila melanogaster. The author has an hindex of 37, co-authored 80 publications receiving 7810 citations. Previous affiliations of Matthew D.W. Piper include Monash University, Clayton campus & University College London.
Papers
More filters
Journal ArticleDOI
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
Susan J. Broughton,Matthew D.W. Piper,Tomoatsu Ikeya,Timothy M. Bass,Jake Jacobson,Yasmine Driege,Pedro Martinez,Ernst Hafen,Dominic J. Withers,Sally J. Leevers,Linda Partridge +10 more
TL;DR: It is shown that ablation of Drosophila insulin-like peptide-producing median neurosecretory cells in the brain leads to increased fasting glucose levels in the hemolymph of adults similar to that found in diabetic mammals and the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation.
Journal ArticleDOI
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila.
TL;DR: Reduced activity of the insulin/insulin-like growth factor signalling pathway extends lifespan in diverse organisms, and it is found that it also protects against the shortening of lifespan with full feeding.
Journal ArticleDOI
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Camilla Burnett,Sara Valentini,Filipe Cabreiro,Martin Goss,Milán Somogyvári,Matthew D.W. Piper,Matthew P. Hoddinott,George L. Sutphin,Vid Leko,Joshua J McElwee,Rafael P. Vázquez-Manrique,Rafael P. Vázquez-Manrique,Anne-Marie Orfila,Anne-Marie Orfila,Daniel Ackerman,Catherine Au,Giovanna Vinti,Michele Riesen,Ken Howard,Christian Neri,Christian Neri,Antonio Bedalov,Matt Kaeberlein,Csaba Soti,Linda Partridge,David Gems +25 more
TL;DR: These findings cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila and underscore the importance of controlling for genetic background and for the mutagenic effects of transgene insertions in studies of genetic effects on lifespan.
Journal ArticleDOI
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
Colin Selman,Steven J. Lingard,Agharul I. Choudhury,Rachel L. Batterham,Marc Claret,Melanie Clements,Faruk Ramadani,Klaus Okkenhaug,Eugene Schuster,Eric Blanc,Matthew D.W. Piper,Hind Al-Qassab,John R. Speakman,Danielle Carmignac,Iain C. A. F. Robinson,Janet M. Thornton,David Gems,Linda Partridge,Dominic J. Withers +18 more
TL;DR: The results suggest that IRS1 signaling is an evolutionarily conserved pathway regulating mammalian life span and may be a point of intervention for therapies with the potential to delay age–related processes.
Journal ArticleDOI
Calories Do Not Explain Extension of Life Span by Dietary Restriction in Drosophila
TL;DR: It is demonstrated that extension of life span by DR in Drosophila is not attributable to the reduction in calorie intake, and reduction of either dietary yeast or sugar can reduce mortality and extend life span, but by an amount that is unrelated to the calorie content of the food.