William B. Mair

TL;DR: Reconstitution of ULK1-deficient cells with a mutant ULK2 that cannot be phosphorylated by AMPK revealed that such phosphorylation is required for mitochondrial homeostasis and cell survival during starvation.

TL;DR: How recent work in nonmammalian model organisms has revealed new insight into the genetics of DR and how the discovery of DR-specific transcription factors will advance the understanding of this phenomenon are discussed.

TL;DR: Dietary restriction in Drosophila extends life-span entirely by reducing the short-term risk of death, and two days after the application of DR at any age for the first time, previously fully fed flies are no more likely to die.

TL;DR: It is demonstrated that extension of life span by DR in Drosophila is not attributable to the reduction in calorie intake, and reduction of either dietary yeast or sugar can reduce mortality and extend life span, but by an amount that is unrelated to the calorie content of the food.

TL;DR: It is found that sulfur amino acid restriction increased expression of the transsulfuration pathway (TSP) enzyme cystathionine γ-lyase (CGL), resulting in increased hydrogen sulfide (H2S) production and protection from hepatic ischemia reperfusion injury, consistent with evolutionary conservation of TSP-mediated H2S as a mediator of DR benefits with broad implications for clinical translation.