M
Matthew I. Hutchings
Researcher at University of East Anglia
Publications - 106
Citations - 5480
Matthew I. Hutchings is an academic researcher from University of East Anglia. The author has contributed to research in topics: Streptomyces coelicolor & Streptomyces. The author has an hindex of 34, co-authored 101 publications receiving 4269 citations. Previous affiliations of Matthew I. Hutchings include University of Southampton & Norwich University.
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Antibiotics: past, present and future
TL;DR: It is argued that the future of antibiotic discovery looks bright as new technologies such as genome mining and editing are deployed to discover new natural products with diverse bioactivities.
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Streptomyces as symbionts; an emerging and widespread theme?
TL;DR: This work reviews what is currently known about the role of streptomycetes as symbionts with fungi, plants and animals and suggests that this field of research will become increasingly important as the search for new antibiotics switches to unusual and under-explored environments.
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Cell envelope stress response in Gram-positive bacteria
TL;DR: The cell envelope stress response will be placed in the context of the overall cellular physiology, demonstrating that its regulatory systems are linked not only to other stress responses but also to the overall homeostasis and lifestyle of Gram-positive bacteria.
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Chemical ecology of antibiotic production by actinomycetes
TL;DR: The environmental triggers and cues that control natural product formation by actinomycetes are reviewed and pointers as to how these insights may be harnessed for drug discovery are provided.
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A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus.
Jörg Barke,Ryan F. Seipke,Sabine Grüschow,Darren Heavens,Nizar Drou,Mervyn J. Bibb,Rebecca J. M. Goss,Douglas W. Yu,Douglas W. Yu,Matthew I. Hutchings +9 more
TL;DR: The results show that a combination of co-evolution and environmental sampling results in the diversity of actinomycete symbionts and antibiotics associated with attine ants.