Antibiotics: past, present and future
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TLDR
It is argued that the future of antibiotic discovery looks bright as new technologies such as genome mining and editing are deployed to discover new natural products with diverse bioactivities.About:
This article is published in Current Opinion in Microbiology.The article was published on 2019-10-01 and is currently open access. It has received 708 citations till now. The article focuses on the topics: Modern medicine & Antibiotic resistance.read more
Citations
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Journal ArticleDOI
Natural products in drug discovery: advances and opportunities.
TL;DR: In this article, the authors summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities, and discuss the potential of using natural products as drug leads.
Journal ArticleDOI
Towards the sustainable discovery and development of new antibiotics
Marcus Miethke,Marco Pieroni,Tilmann Weber,Mark Brönstrup,Peter Hammann,Ludovic Halby,Paola B. Arimondo,Philippe Glaser,Bertrand Aigle,Helge B. Bode,Helge B. Bode,Rui Moreira,Yanyan Li,Andriy Luzhetskyy,Marnix H. Medema,Jean-Luc Pernodet,Marc Stadler,José R. Tormo,Olga Genilloud,Andrew W. Truman,Kira J. Weissman,Eriko Takano,Stefano Sabatini,Evi Stegmann,Heike Brötz-Oesterhelt,Wolfgang Wohlleben,Myriam Seemann,Martin Empting,Anna K. H. Hirsch,Brigitta Loretz,Claus-Michael Lehr,Alexander Titz,Jennifer Herrmann,Timo Jaeger,Silke Alt,Thomas Hesterkamp,Mathias Winterhalter,Andrea Schiefer,Kenneth Pfarr,Achim Hoerauf,Heather Graz,Michael Graz,Mika Lindvall,Savithri Ramurthy,Anders Karlén,Maarten van Dongen,Hrvoje Petković,Andreas Keller,Frédéric Peyrane,Stefano Donadio,Laurent Fraisse,Laura J. V. Piddock,Ian H. Gilbert,Heinz E. Moser,Rolf Müller +54 more
TL;DR: In this paper, the authors present a strategic blueprint to substantially improve our ability to discover and develop new antibiotics, and propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding.
Journal ArticleDOI
Prevalence and hazardous impact of pharmaceutical and personal care products and antibiotics in environment: A review on emerging contaminants
Preeti Chaturvedi,Preeti Chaturvedi,Parul Shukla,Balendu Shekher Giri,Pankaj Chowdhary,Ram Chandra,Pratima Gupta,Ashok Pandey +7 more
TL;DR: In this article, the major sources responsible for emergence of antibiotic resistance are elucidated and a variety of introductory sources and fate of PPCPs in aquatic environment including human and veterinary wastes, aquaculture and agriculture related wastes, and other anthropogenic activities have been discussed.
Journal ArticleDOI
Antibiotics in wastewater: From its occurrence to the biological removal by environmentally conscious technologies.
TL;DR: In this paper, the authors explored the most recent advances about the fate of antibiotics on biological wastewater treatment plants (WWTP) and analyzed the role of the antibiotic properties and the process operating conditions.
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Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria.
Kotaro Kiga,Xin Ee Tan,Rodrigo Ibarra-Chávez,Shinya Watanabe,Yoshifumi Aiba,Yusuke Sato’o,Feng-Yu Li,Teppei Sasahara,Bintao Cui,Moriyuki Kawauchi,Tanit Boonsiri,Kanate Thitiananpakorn,Yusuke Taki,Aa Haeruman Azam,Masato Suzuki,José R. Penadés,Longzhu Cui +16 more
TL;DR: A bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes is developed and it is demonstrated that the CapsidCas13a(s) can be applied to detect bacterial genes through gene-specific depletion of bacteria without employing nucleic acid manipulation and optical visualization devices.
References
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Journal ArticleDOI
Natural Products as Sources of New Drugs from 1981 to 2014
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and 2012, and the time frame has been extended to cover the 34 years from January 1, 1981, to December 31, 2014, for all diseases worldwide, and from 1950 (earliest so far identified) to December 2014 for all approved antitumor drugs worldwide.
Journal ArticleDOI
Drugs for bad bugs: confronting the challenges of antibacterial discovery
TL;DR: The experience of evaluating more than 300 genes and 70 high-throughput screening campaigns over a period of 7 years is shared, and what is learned is looked at and how that has influenced GlaxoSmithKline's antibacterials strategy going forward.
Journal ArticleDOI
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
Kai Blin,Simon Shaw,Katharina Steinke,Rasmus Villebro,Nadine Ziemert,Sang Yup Lee,Sang Yup Lee,Marnix H. Medema,Tilmann Weber +8 more
TL;DR: AntiSMASH 5 adds detection rules for clusters encoding the biosynthesis of acyl-amino acids, β-lactones, fungal RiPPs, RaS-Ri PPs, polybrominated diphenyl ethers, C-nucleosides, PPY-like ketones and lipolanthines and provides more detailed predictions for type II polyketide synthase-encoding gene clusters.
Journal ArticleDOI
A new antibiotic kills pathogens without detectable resistance
Losee Lucy Ling,Tanja Schneider,Aaron J. Peoples,Amy Spoering,Ina Engels,Brian P. Conlon,A. Mueller,Till F. Schäberle,Dallas Hughes,Slava S. Epstein,M. Jones,Linos Lazarides,Victoria Alexandra Steadman,Cohen Dr,Cintia R. Felix,Fetterman Ka,William Millett,Anthony Nitti,Ashley Zullo,Chao Chen,Kim Lewis +20 more
TL;DR: The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance, as well as several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors.
Journal Article
On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to their Use in the Isolation of B. influenzæ
TL;DR: It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes, and its value as an aid to the isolation of B. influenzae has been demonstrated.
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