Matthew J. Marton

TL;DR: It is proposed that GCN1 is not needed forGCN2 kinase activity per se but is required for in vivo activation of GCN2 in response to the starvation signal, uncharged tRNA.

TL;DR: Insight is given into the mechanisms and physiological importance of pathway insulation and the signaling properties of kinase fusions support a model in which scaffold proteins dictate substrate choice and promote pathway specificity by presenting preferred substrates in high local concentration.

TL;DR: Nine genes are discussed, which showed the most promising SCLC tumor to normal tissue differential expression profiles, including seven known and two novel genes.

TL;DR: In vivo interactions between eEF3 and eEF1A are critical for protein synthesis, and a temperature-sensitive allele of the YEF3 gene is identified, which increases sensitivity to aminoglycosidic drugs, causes a 50% reduction of total protein synthesis at permissive temperatures, and slows run-off of polyribosomes.

TL;DR: In this paper, a plurality of cellular constituents are measured to determine the activity of a drug on a target pathway and at least one off-target pathway, and a drug specificity is determined by comparing the target and off target activities of the drug.