M
Michael R. Meyer
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 144
Citations - 14947
Michael R. Meyer is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Stars & Planetary system. The author has an hindex of 56, co-authored 144 publications receiving 14621 citations. Previous affiliations of Michael R. Meyer include ETH Zurich & Steward Health Care System.
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Journal ArticleDOI
Functional Discovery via a Compendium of Expression Profiles
Timothy P. Hughes,Matthew J. Marton,Allan R. Jones,Christopher J. Roberts,Roland Stoughton,Christopher D. Armour,Holly A. Bennett,Ernest M. Coffey,Hongyue Dai,Yudong D. He,Matthew J. Kidd,Amy M King,Michael R. Meyer,David J. Slade,Pek Yee Lum,Sergey B. Stepaniants,Daniel D. Shoemaker,Daniel J Gachotte,Kalpana Chakraburtty,Julian A. Simon,Martin Bard,Stephen H. Friend +21 more
TL;DR: A reference database or "compendium" of expression profiles corresponding to 300 diverse mutations and chemical treatments in S. cerevisiae is constructed, and it is shown that the cellular pathways affected can be determined by pattern matching, even among very subtle profiles.
Journal ArticleDOI
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer.
Timothy P. Hughes,Mao Mao,Allan R. Jones,Julja Burchard,Matthew J. Marton,Karen W. Shannon,Steven M. Lefkowitz,Michael Ziman,Janell M. Schelter,Michael R. Meyer,Sumire Kobayashi,Colleen P. Davis,Hongyue Dai,Yudong D. He,Sergey B. Stephaniants,Guy Cavet,Wynn L. Walker,Anne E. West,Ernest M. Coffey,Daniel D. Shoemaker,Roland Stoughton,Alan P. Blanchard,Stephen H. Friend,Peter S. Linsley +23 more
TL;DR: It is found that 60-mer oligonucleotides reliably detect transcript ratios at one copy per cell in complex biological samples, and that ink-jet arrays are compatible with several different sample amplification and labeling techniques.
Journal ArticleDOI
Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles
Christopher J. Roberts,Bryce Nelson,Matthew J. Marton,Roland Stoughton,Michael R. Meyer,Holly A. Bennett,Yudong D. He,Hongyue Dai,Wynn L. Walker,Timothy P. Hughes,Mike Tyers,Charles Boone,Stephen H. Friend +12 more
TL;DR: Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response and global transcript analysis reflects biological responses associated with the activation and perturbation of signalTransduction pathways.
Journal ArticleDOI
Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast
Krishnamurthy Natarajan,Michael R. Meyer,Belinda M. Jackson,David J. Slade,Christopher J. Roberts,Alan G. Hinnebusch,Matthew J. Marton +6 more
TL;DR: The broad transcriptional response evoked by Gcn4p is produced by diverse stress conditions, and numerous genes encoding protein kinases and transcription factors were identified as targets, suggesting that Gcn 4p is a master regulator of gene expression.
Journal ArticleDOI
Drug target validation and identification of secondary drug target effects using DNA microarrays
Matthew J. Marton,Joseph L. DeRisi,Holly A. Bennett,Vishwanath R. Iyer,Michael R. Meyer,Christopher J. Roberts,Roland Stoughton,Julja Burchard,David J. Slade,Hongyue Dai,Douglas E. Bassett,Leland H. Hartwell,Patrick O. Brown,Stephen H. Friend +13 more
TL;DR: The described method permits the direct confirmation of drug targets and recognition of drug-dependent changes in gene expression that are modulated through pathways distinct from the drug's intended target.