M
Matthew J. Marton
Researcher at National Institutes of Health
Publications - 25
Citations - 18056
Matthew J. Marton is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & DNA microarray. The author has an hindex of 17, co-authored 23 publications receiving 17472 citations. Previous affiliations of Matthew J. Marton include Agilent Technologies.
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Journal ArticleDOI
Drug target validation and identification of secondary drug target effects using DNA microarrays
Matthew J. Marton,Joseph L. DeRisi,Holly A. Bennett,Vishwanath R. Iyer,Michael R. Meyer,Christopher J. Roberts,Roland Stoughton,Julja Burchard,David J. Slade,Hongyue Dai,Douglas E. Bassett,Leland H. Hartwell,Patrick O. Brown,Stephen H. Friend +13 more
TL;DR: The described method permits the direct confirmation of drug targets and recognition of drug-dependent changes in gene expression that are modulated through pathways distinct from the drug's intended target.
Journal ArticleDOI
Widespread aneuploidy revealed by DNA microarray expression profiling.
Timothy P. Hughes,Christopher J. Roberts,Hongyue Dai,Allan R. Jones,Michael R. Meyer,David J. Slade,Julja Burchard,Sally Dow,Teresa R. Ward,Matthew J. Kidd,Stephen H. Friend,Matthew J. Marton +11 more
TL;DR: The general usefulness of expression profiles for nearly 300 Saccharomyces cerevisiae deletion mutants, obtained recently, is demonstrated, with implications for interpreting whole-genome expression data, particularly from cells known to suffer genomic instability, such as malignant or immortalized cells.
Journal ArticleDOI
Experimental annotation of the human genome using microarray technology
Daniel D. Shoemaker,Eric E. Schadt,Christopher D. Armour,Yudong D. He,Philip W. Garrett-engele,Paul McDonagh,Patrick M. Loerch,Amy Leonardson,Pek Yee Lum,Guy Cavet,Lani F. Wu,Steven J. Altschuler,Seve Edwards,Jason R. King,J. S. Tsang,Greg Schimmack,Janell M. Schelter,J. Koch,Michael Ziman,Matthew J. Marton,B. Li,P. Cundiff,Thomas R. Ward,John C. Castle,M. Krolewski,Miriam Meyer,Mao Mao,Julja Burchard,Matthew J. Kidd,Hongyue Dai,John W. Phillips,Peter S. Linsley,Roland Stoughton,Stephen W. Scherer,M. S. Boguski +34 more
TL;DR: Using ‘exon’ and ‘tiling’ arrays fabricated by ink-jet oligonucleotide synthesis, an experimental approach is devised to validate and refine computational gene predictions and define full-length transcripts on the basis of co-regulated expression of their exons.
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Effects of atmospheric ozone on microarray data quality.
Thomas L. Fare,Ernest M. Coffey,Hongyue Dai,Yudong D. He,Deborah A. Kessler,Kristopher A. Kilian,John E. Koch,Eric M. Leproust,Matthew J. Marton,Michael R. Meyer,Roland B. Stoughton,George Y. Tokiwa,Yanqun Wang +12 more
TL;DR: Control exposures of microarrays to ozone confirmed this factor as the root cause, and data is presented that shows susceptibility of a class of cyanine dyes to ozone levels as low as 5-10 ppb for periods as short as 10-30 s.
Journal ArticleDOI
Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.
TL;DR: It is proposed that GCN1 performs an EF3-related function in facilitating the activation of GCN2 by uncharged tRNA on translating ribosomes, which may operate in yeast and human cells.