M
Matthew J. Picklo
Researcher at Agricultural Research Service
Publications - 119
Citations - 3760
Matthew J. Picklo is an academic researcher from Agricultural Research Service. The author has contributed to research in topics: Polyunsaturated fatty acid & Docosahexaenoic acid. The author has an hindex of 31, co-authored 108 publications receiving 3330 citations. Previous affiliations of Matthew J. Picklo include United States Department of Agriculture & University of North Dakota.
Papers
More filters
Journal ArticleDOI
Carbonylation of Adipose Proteins in Obesity and Insulin Resistance Identification of Adipocyte Fatty Acid-binding Protein as a Cellular Target of 4-Hydroxynonenal
TL;DR: Results indicate that obesity is accompanied by an increase in the carbonylation of a number of adipose-regulatory proteins that may serve as a mechanistic link between increased oxidative stress and the development of insulin resistance.
Journal ArticleDOI
The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism.
TL;DR: Data revealing the Nrf2 pathway's regulatory role in energy metabolism at the molecular, cellular and whole animal levels is examined to provide novel insights for nutritional interventions for obesity and its comorbidities such as diabetes.
Journal ArticleDOI
Carbonyl toxicology and Alzheimer's disease.
TL;DR: This review examines the role that carbonyls may play in the development of Alzheimer's disease and the evidence for their involvement in AD, and the potential mechanisms that the brain utilizes to detoxify carbonyl species and possible therapeutic interventions based oncarbonyl detoxification.
Journal ArticleDOI
Trans-4-hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: Make some room HNE…
TL;DR: It is clear that further study is needed to determine the biochemical and physiological roles of HHE and its related aldehyde, trans-4-oxo-2-hexenal, but there are important differences particularly with respect to adduction targets and detoxification pathways.
Journal ArticleDOI
Central noradrenergic lesioning using anti-DBH-saporin: anatomical findings
TL;DR: Results show that alpha-DBH-sap efficiently and selectively destroys CNS noradrenergic neurons after i.c.v. injection, and the preferential destruction of locus coeruleus, A5, and A7 over A1/C1 and A2/C 2/C3 may be due to more efficient access of the immunotoxin to these neurons and their terminals.