Matthias Kern

TL;DR: In this paper, the association between obesity and impaired insulin sensitivity has been recognized, although a subgroup of obese individuals seems to be protected from insulin resistance, while the rest of the population appears to be obese.

TL;DR: Nrg4 is established as a brown fat–enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).

TL;DR: Findings indicate that the adipsin/C3a pathway connects adipocyte function to β cell physiology, and manipulation of this molecular switch may serve as a therapy in T2DM.

TL;DR: The role of omental and subcutaneous adipose tissue chemerin and CMKLR1 messenger RNA (mRNA) expression in human obesity is investigated and the hypothesis that changes inChemerin serum concentrations are primarily associated with reduced body fat mass is tested in the context of 3 weight loss intervention studies.

TL;DR: Both peripheral and central vaspin administration decrease food intake in obese db/db and lean C57BL/6 mice and in the cerebrospinal fluid of healthy individuals, suggesting a previously unrecognised role of vaspIn in the regulation of food intake.