Adipsin is an Adipokine that Improves β Cell Function in Diabetes
James C. Lo,James C. Lo,Sanda Ljubicic,Barbara Leibiger,Matthias Kern,Ingo B. Leibiger,Tilo Moede,Molly E. Kelly,Diti Chatterjee Bhowmick,Incoronata Murano,Paul Cohen,Paul Cohen,Alexander S. Banks,Melin J. Khandekar,Arne Dietrich,Jeffrey S. Flier,Saverio Cinti,Matthias Blüher,Nika N. Danial,Per Olof Berggren,Bruce M. Spiegelman +20 more
TLDR
Findings indicate that the adipsin/C3a pathway connects adipocyte function to β cell physiology, and manipulation of this molecular switch may serve as a therapy in T2DM.About:
This article is published in Cell.The article was published on 2014-07-03 and is currently open access. It has received 277 citations till now. The article focuses on the topics: Insulin.read more
Citations
More filters
Journal ArticleDOI
Insulin action and resistance in obesity and type 2 diabetes
TL;DR: This Perspective reviews alternate viewpoints and recent results on the temporal and mechanistic connections between hyperinsulinemia, obesity and insulin resistance and connects insulin resistance to extensive metabolic cross-talk between the liver, adipose tissue, pancreas and skeletal muscle.
Journal ArticleDOI
Adipokines in health and disease
TL;DR: Secretion of adipokines, including leptin, adiponectin, fibroblast growth factor 21, retinol-binding protein 4 (RBP4), dipeptidyl peptidase 4 (DPP-4), bone morphogenetic protein (BMP)-4, BMP-7, vaspin, apelin, and progranulin, is altered in adipose tissue dysfunction and may contribute to a spectrum of obesity-associated diseases.
Journal ArticleDOI
Adipocyte dysfunction, inflammation and metabolic syndrome
Nora Klöting,Matthias Blüher +1 more
TL;DR: Most likely, impaired adipocyte function is caused by genetic, behavioural and environmental factors which are not entirely understood, and elucidating the mechanisms of adipocyte dysfunction may lead to the identification of novel treatment targets for obesity and the MetS.
Journal ArticleDOI
The endocrine function of adipose tissues in health and cardiometabolic disease
Ludger Scheja,Joerg Heeren +1 more
TL;DR: The functional role of adipose tissue-derived endocrine hormones for metabolic adaptations to the environment and how these factors contribute to the development of cardiometabolic diseases are discussed.
Journal ArticleDOI
Complement activation, regulation, and molecular basis for complement‐related diseases
TL;DR: An integrated and updated view of complement is presented based on structural and functional data and the new roles attributed to complement are described and the structural and mechanistic understanding of the complement system rationalizes the genetic defects conferring uncontrolled activation or other undesirable effects of complement.
References
More filters
Journal ArticleDOI
Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
Journal ArticleDOI
Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.
Journal ArticleDOI
Inflammation and insulin resistance
TL;DR: The evolving concept of insulin resistance and T2D as having immunological components and an improving picture of how inflammation modulates metabolism provide new opportunities for using antiinflammatory strategies to correct the metabolic consequences of excess adiposity.
Journal ArticleDOI
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
TL;DR: Diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance.
Journal ArticleDOI
Adipokines in inflammation and metabolic disease
TL;DR: The role of adipokines in inflammatory responses is focused on and their potential as regulators of metabolic function is discussed.