A
Arne Dietrich
Researcher at Leipzig University
Publications - 147
Citations - 4318
Arne Dietrich is an academic researcher from Leipzig University. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 28, co-authored 125 publications receiving 3298 citations.
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Journal ArticleDOI
Insulin-sensitive obesity
Nora Klöting,Mathias Fasshauer,Arne Dietrich,Peter Kovacs,Michael R. Schön,Matthias Kern,Michael Stumvoll,Matthias Blüher +7 more
TL;DR: In this paper, the association between obesity and impaired insulin sensitivity has been recognized, although a subgroup of obese individuals seems to be protected from insulin resistance, while the rest of the population appears to be obese.
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The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis
Guoxiao Wang,Xu Yun Zhao,Zhuo Xian Meng,Matthias Kern,Arne Dietrich,Zhimin Chen,Zoharit Cozacov,Dequan Zhou,Adewole L. Okunade,Xiong Su,Siming Li,Matthias Blüher,Jiandie D. Lin +12 more
TL;DR: Nrg4 is established as a brown fat–enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).
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Adipsin is an Adipokine that Improves β Cell Function in Diabetes
James C. Lo,James C. Lo,Sanda Ljubicic,Barbara Leibiger,Matthias Kern,Ingo B. Leibiger,Tilo Moede,Molly E. Kelly,Diti Chatterjee Bhowmick,Incoronata Murano,Paul Cohen,Paul Cohen,Alexander S. Banks,Melin J. Khandekar,Arne Dietrich,Jeffrey S. Flier,Saverio Cinti,Matthias Blüher,Nika N. Danial,Per Olof Berggren,Bruce M. Spiegelman +20 more
TL;DR: Findings indicate that the adipsin/C3a pathway connects adipocyte function to β cell physiology, and manipulation of this molecular switch may serve as a therapy in T2DM.
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Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes.
Andreas Oberbach,Matthias Blüher,Henry Wirth,Henry Wirth,Holger Till,Peter Kovacs,Yvonne Kullnick,Nadine Schlichting,Janina M. Tomm,Ulrike Rolle-Kampczyk,Jayaseelan Murugaiyan,Hans Binder,Arne Dietrich,Martin von Bergen +13 more
TL;DR: The combined serum proteomic and metabolomic profiling reveals a link between the complement system and obesity and identifies both novel (C3b, CLU, VDBP, and all metabolites) and confirms previously discovered markers of body fat mass changes.
Journal ArticleDOI
Adipose Dipeptidyl Peptidase-4 and Obesity: Correlation with insulin resistance and depot-specific release from adipose tissue in vivo and in vitro
Henrike Sell,Matthias Blüher,Nora Klöting,Raphaela Schlich,Miriam Willems,Florian Ruppe,Wolfram T. Knoefel,Arne Dietrich,Barbara A. Fielding,Barbara A. Fielding,Peter Arner,Keith N. Frayn,Jürgen Eckel +12 more
TL;DR: DPP4, a novel adipokine, has a higher release from VAT that is particularly pronounced in obese and insulin-resistant patients, suggesting that DPP4 may be a marker for visceral obesity, insulin resistance, and the metabolic syndrome.