M
Matthijs Raaben
Researcher at Netherlands Cancer Institute
Publications - 34
Citations - 3439
Matthijs Raaben is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Coronavirus & Viral replication. The author has an hindex of 20, co-authored 34 publications receiving 2870 citations. Previous affiliations of Matthijs Raaben include Utrecht University & Harvard University.
Papers
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The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access
Marlieke L.M. Jongsma,Matthijs Raaben,Antonius A. de Waard,Tao Zhang,Birol Cabukusta,René Platzer,Vincent A. Blomen,Anastasia Xagara,Tamara Verkerk,Sophie Bliss,Lennert Janssen,Elmer Stickel,Stephanie Holst,Rosina Plomp,Arend Mulder,Soldano Ferrone,Frans H.J. Claas,Mirjam H.M. Heemskerk,Marieke Griffioen,Hermen S. Overkleeft,Johannes B. Huppa,Manfred Wuhrer,Thijn R. Brummelkamp,Thijn R. Brummelkamp,Jacques Neefjes,Robbert M. Spaapen,Robbert M. Spaapen +26 more
TL;DR: Overall, this study identifies a GSL signature that functionally inhibits antigen presentation and represents a potential therapeutic target in cancer, infection and autoimmunity.
Patent
Analysis of identifying genetic elements affecting phenotype
Thijn R. Brummelkamp,Joppe Nieuwenhuis,Lucas T. Jae,Markus Brockmann,Blomen Vincent Arthur,Matthijs Raaben +5 more
TL;DR: In this paper, a set of methods for identifying endogenous physiologically relevant genetic elements that affect a intracellular phenotype of interest is presented. But the methods are not suitable for the detection of genes that are involved in human health conditions.
Journal ArticleDOI
Identification of potential immunotherapeutic targets in antigen presentation and costimulation networks
Robbert M. Spaapen,Vincent A. Blomen,Peter A. van Veelen,Marlieke L.M. Jongsma,Lennert Janssen,George M.C. Janssen,Matthijs Raaben,Thijn R. Brummelkamp,Jacques Neefjes +8 more
TL;DR: A near-complete map of the intracellular network behind MHC-I and costimulatory molecule cell surface expression is built, arguing for an unexpected immune-independent regulation of the antigen presentation pathway.
Patent
Assays to identify genetic elements affecting phenotype
Thijn R. Brummelkamp,Joppe Nieuwenhuis,Lucas T. Jae,Markus Brockmann,Blomen Vincent Arthur,Matthijs Raaben +5 more
TL;DR: In this paper, a set of methods for identifying endogenous physiologically relevant genetic elements that affect a intracellular phenotype of interest is presented, where non-living cells that have been subjected to a mutagenesis treatment are sorted based on phenotype and analyzed to identify the genetic element.