Mattia Albiero

TL;DR: It is demonstrated that EPC decrease is related to PAD severity and that E PC function is altered in diabetic subjects with PAD, strengthening the pathogenetic role of EPC dysregulation in diabetic vasculopathy.

TL;DR: In patients with diabetes, endothelial dysfunction appears to be a consistent finding; indeed, there is general agreement that hyperglycemia and diabetes lead to an impairment of NO production and activity.

TL;DR: It is found that sedentary but not active humans display an age-related decline in the mitochondrial protein, optic atrophy 1 (OPA1), that is associated with muscle loss and can trigger a cascade of signaling initiated at the ER that systemically affects general metabolism and aging.

TL;DR: The impaired glucose metabolism induced by muscle-specific Bmal1 knockout suggests that a major physiological role of the muscle clock is to prepare for the transition from the rest/fasting phase to the active/feeding phase, when glucose becomes the predominant fuel for skeletal muscle.

TL;DR: Sitagliptin increases circulating EPCs in type 2 diabetic patients with concomitant upregulation of SDF-1α and this ancillary effect of DPP-4 inhibition might have potential favorable cardiovascular implications.