Mattia L. DiFrancesco

TL;DR: Conjugated polymer nanoparticles mediate light-evoked stimulation of retinal neurons and persistently rescue visual functions when subretinally injected in a rat model of retinitis pigmentosa, offering a potential new treatment option for inherited retinal dystrophies and late-stage age-related macular degeneration.

TL;DR: In this paper, the state-of-the-art in the use of graphene materials to engineer three-dimensional scaffolds to drive neuronal growth and regeneration in vivo, and the possibility of using graphene as a component of hybrid composites/multi-layer organic electronics devices.

TL;DR: It is concluded that IKACh plays a critical role in the kinetics of heart rate recovery to resting levels after sympathetic stimulation or after direct β-adrenergic stimulation of pacemaker activity.

TL;DR: It is demonstrated that in neurons loaded with the Ziapin2 compound, millisecond pulses of visible light induce a transient hyperpolarization followed by a delayed depolarization that triggers action potential firing and these effects are persistent and can be evoked in vivo up to 7 days, proving the potential of ZiAPin2 for the modulation of membrane capacitance in the millisecond timescale.

TL;DR: The data support the idea that PB1-F2 is able to form protein channel pores with no appreciable selectivity in membranes and that the c-terminus is important for this function, which could be important for drug development.