M
Maura Coughlin
Researcher at St. Jude Children's Research Hospital
Publications - 7
Citations - 2936
Maura Coughlin is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Stress granule & Oculopharyngeal muscular dystrophy. The author has an hindex of 5, co-authored 6 publications receiving 2077 citations.
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Journal ArticleDOI
Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
Amandine Molliex,Jamshid Temirov,Jihun Lee,Maura Coughlin,Anderson P. Kanagaraj,Hong Joo Kim,Tanja Mittag,J. Paul Taylor +7 more
TL;DR: It is demonstrated that the disease-related RBP hnRNPA1 undergoes liquid-liquid phase separation (LLPS) into protein-rich droplets mediated by a low complexity sequence domain (LCD), and suggested that LCD-mediated LLPS contributes to the assembly of stress granules and their liquid properties.
Journal ArticleDOI
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
Kyung-Ha Lee,Peipei Zhang,Hong Joo Kim,Diana M. Mitrea,Mohona Sarkar,Brian D. Freibaum,Jaclyn A Cika,Maura Coughlin,James Messing,Amandine Molliex,Brian A. Maxwell,Nam Chul Kim,Jamshid Temirov,Jennifer Moore,Regina-Maria Kolaitis,Timothy I. Shaw,Bing Bai,Junmin Peng,Richard W. Kriwacki,Richard W. Kriwacki,J. Paul Taylor +20 more
TL;DR: It is found that arginine-containing DPRs, polyGly-Arg (GR) and polyPro- Arg (PR), interact with RNA-binding proteins and proteins with low complexity sequence domains (LCDs) that often mediate the assembly of membrane-less organelles.
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Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
Lin Guo,Hong Joo Kim,Hejia Wang,John Monaghan,Fernande Freyermuth,Julie C. Sung,Kevin J. O'Donovan,Charlotte M. Fare,Zamia Diaz,Nikita Singh,Zi Chao Zhang,Zi Chao Zhang,Maura Coughlin,Elizabeth A. Sweeny,Morgan E. DeSantis,Meredith E. Jackrel,Christopher B. Rodell,Jason A. Burdick,Oliver D. King,Aaron D. Gitler,Clotilde Lagier-Tourenne,Udai Bhan Pandey,Yuh Min Chook,J. Paul Taylor,J. Paul Taylor,James Shorter +25 more
TL;DR: Karyopherin-β2 prevents RBPs with PY-NLSs accumulating in stress granules, restores nuclear RBP localization and function, and rescues degeneration caused by disease-linked FUS and hnRNPA2, establishing that NIRs therapeutically restore RBP homeostasis and mitigate neurodegeneration.
Journal ArticleDOI
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Christian Haenig,Nir Atias,Alexander K. Taylor,Arnon Mazza,Martin Schaefer,Martin Schaefer,Jenny Russ,Sean Patrick Riechers,Shushant Jain,Maura Coughlin,Jean-Fred Fontaine,Jean-Fred Fontaine,Brian D. Freibaum,Lydia Brusendorf,Martina Zenkner,Pablo Porras,Pablo Porras,Martin Stroedicke,Sigrid Schnoegl,Kristin Arnsburg,Annett Boeddrich,Lucia Pigazzini,Peter Heutink,J. Paul Taylor,J. Paul Taylor,Janine Kirstein,Miguel A. Andrade-Navarro,Miguel A. Andrade-Navarro,Roded Sharan,Erich E. Wanker +29 more
TL;DR: An interactome map that focuses on neurodegenerative disease (ND), connects ∼5,000 human proteins via ∼30,000 candidate interactions and is generated by systematic yeast two-hybrid interaction screening of ∼500 ND-related proteins and integration of literature interactions is reported.
Journal ArticleDOI
hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation.
Cristina Batlle,Peiguo Yang,Maura Coughlin,James Messing,James Messing,Mireia Pesarrodona,Elzbieta Szulc,Xavier Salvatella,Hong Joo Kim,J. Paul Taylor,J. Paul Taylor,Salvador Ventura +11 more
TL;DR: It is shown that D378H/N disease mutations impact hnRNPDL assembly properties, accelerating aggregation and dramatically reducing the protein solubility in the muscle of Drosophila, suggesting a genetic loss-of-function mechanism for this muscular disorder.