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Diana M. Mitrea
Researcher at St. Jude Children's Research Hospital
Publications - 36
Citations - 4591
Diana M. Mitrea is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 28 publications receiving 3191 citations. Previous affiliations of Diana M. Mitrea include State University of New York Upstate Medical University.
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Journal ArticleDOI
Coexisting Liquid Phases Underlie Nucleolar Subcompartments
Marina Feric,Nilesh Vaidya,Tyler S. Harmon,Diana M. Mitrea,Lian Zhu,Tiffany M. Richardson,Richard W. Kriwacki,Rohit V. Pappu,Clifford P. Brangwynne +8 more
TL;DR: It is shown that subcompartments within the nucleolus represent distinct, coexisting liquid phases that may facilitate sequential RNA processing reactions in a variety of RNP bodies, and suggested that phase separation can give rise to multilayered liquids.
Journal ArticleDOI
Phase separation in biology; functional organization of a higher order
TL;DR: This review discusses the functional roles of membrane-less organelles, unifying structural and mechanistic principles that underlie their assembly and disassembly, and established and emerging methods used in structural investigations of membranes-lessorganelles.
Journal ArticleDOI
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
Kyung-Ha Lee,Peipei Zhang,Hong Joo Kim,Diana M. Mitrea,Mohona Sarkar,Brian D. Freibaum,Jaclyn A Cika,Maura Coughlin,James Messing,Amandine Molliex,Brian A. Maxwell,Nam Chul Kim,Jamshid Temirov,Jennifer Moore,Regina-Maria Kolaitis,Timothy I. Shaw,Bing Bai,Junmin Peng,Richard W. Kriwacki,Richard W. Kriwacki,J. Paul Taylor +20 more
TL;DR: It is found that arginine-containing DPRs, polyGly-Arg (GR) and polyPro- Arg (PR), interact with RNA-binding proteins and proteins with low complexity sequence domains (LCDs) that often mediate the assembly of membrane-less organelles.
Journal ArticleDOI
Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
Diana M. Mitrea,Jaclyn A Cika,Jaclyn A Cika,Clifford S. Guy,David Ban,Priya R. Banerjee,Christopher B. Stanley,Amanda Nourse,Ashok A. Deniz,Richard W. Kriwacki,Richard W. Kriwacki +10 more
TL;DR: It is shown that nucleophosmin (NPM1) integrates within the nucleolus via a multi-modal mechanism involving multivalent interactions with proteins containing arginine-rich linear motifs (R-motifs) and ribosomal RNA (rRNA), which are found in canonical nucleolar localization signals.
Journal ArticleDOI
Composition-dependent thermodynamics of intracellular phase separation
Joshua A. Riback,Lian Zhu,Mylene C. Ferrolino,Michele Tolbert,Diana M. Mitrea,David W. Sanders,Ming-Tzo Wei,Richard W. Kriwacki,Clifford P. Brangwynne +8 more
TL;DR: It is found that heterotypic interactions among protein and RNA components stabilize various archetypal intracellular condensates—including the nucleolus, Cajal bodies, stress granules and P-bodies—implying that the composition of condensate is finely tuned by the thermodynamics of the underlying biomolecular interaction network.