M
Maureen A. Leehey
Researcher at University of Colorado Denver
Publications - 99
Citations - 10291
Maureen A. Leehey is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Fragile X-associated tremor/ataxia syndrome & Ataxia. The author has an hindex of 47, co-authored 92 publications receiving 9536 citations. Previous affiliations of Maureen A. Leehey include Veterans Health Administration & University of Colorado Boulder.
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Journal ArticleDOI
Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X.
Randi J Hagerman,Maureen A. Leehey,W. Heinrichs,Flora Tassone,Robert S. Wilson,J. Hills,Jim Grigsby,B. Gage,Paul J. Hagerman +8 more
TL;DR: In this article, the authors reported five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy, and they had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein.
Journal ArticleDOI
Fragile X Premutation Tremor/Ataxia Syndrome: Molecular, Clinical, and Neuroimaging Correlates
Sébastien Jacquemont,Randi J Hagerman,Maureen A. Leehey,Jim Grigsby,Lin Zhang,James A. Brunberg,Claudia M. Greco,Vincent des Portes,Tristan Jardini,Richard A. Levine,Elizabeth Berry-Kravis,W. Ted Brown,Stephane Schaeffer,John T. Kissel,Flora Tassone,Paul J. Hagerman +15 more
TL;DR: The clinical presentation of these patients, coupled with a specific lesion visible on magnetic resonance imaging and with neuropathological findings, affords a more complete delineation of this fragile X premutation-associated tremor/ataxia syndrome and distinguishes it from other movement disorders.
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Penetrance of the Fragile X–Associated Tremor/Ataxia Syndrome in a Premutation Carrier Population
Sébastien Jacquemont,Randi J Hagerman,Maureen A. Leehey,Deborah A. Hall,Richard A. Levine,James A. Brunberg,Lin Zhang,Tristan Jardini,Louise W. Gane,Susan W. Harris,Kristin Herman,James P. Grigsby,Claudia M. Greco,Elizabeth Berry-Kravis,Flora Tassone,Paul J. Hagerman +15 more
TL;DR: It is demonstrated that older male carriers of premutation alleles of the FMR1 gene are at high risk of developing fragile X-associated tremor/ataxia syndrome (FXTAS), and older men with ataxia and intention tremor should be screened for the F MR1 mutation.
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AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial
Peter A. LeWitt,Ali R. Rezai,Maureen A. Leehey,Steven G. Ojemann,Alice W. Flaherty,Emad N. Eskandar,Sandra K. Kostyk,Karen Thomas,Atom Sarkar,Mustafa S. Siddiqui,Stephen B. Tatter,Jason M. Schwalb,Kathleen L. Poston,Jaimie M. Henderson,Roger Kurlan,Irene H. Richard,Lori Van Meter,Christine V. Sapan,Matthew J. During,Michael G. Kaplitt,Andrew Feigin +20 more
TL;DR: The efficacy and safety of bilateral infusion of AAV2-GAD in the subthalamic nucleus supports its further development for Parkinson's disease and shows the promise for gene therapy for neurological disorders.
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Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriers.
Claudia M. Greco,Randi J Hagerman,Flora Tassone,Albert E. Chudley,M. R. Del Bigio,Sébastien Jacquemont,Maureen A. Leehey,Paul J. Hagerman +7 more
TL;DR: The presence of inclusions in the brains of all four FXS carriers with the neurological findings provides further support for a unique clinical entity associated with pre-mutation FMR1 alleles.