Journal ArticleDOI
Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: Involvement of the monoaminergic system
Daniele G. Machado,Luis E.B. Bettio,Mauricio P. Cunha,Juliano C. Capra,Juliana Bastos Dalmarco,Moacir Geraldo Pizzolatti,Ana Lúcia S. Rodrigues +6 more
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TLDR
The results suggest that the antidepressant action of the extract of R. officinalis is mediated by an interaction with the monoaminergic system and that this plant should be further investigated as an alternative therapeutic approach for the treatment of depression.Abstract:
Rosemary, Rosmarinus officinalis L. (Labiatae) has several therapeutic applications in folk medicine in curing or managing a wide range of diseases, including depression. In this study, the effect of the hydroalcoholic extract of the stems and leaves of this plant was investigated in two behavioral models, the forced swimming test (FST) and tail suspension test (TST) in mice. The extract of R. officinalis produced an antidepressant-like effect, since the acute treatment of mice with the extract by p.o. route significantly reduced the immobility time in the FST (100 mg/kg) and TST (10-100 mg/kg), as compared to a control group, without accompanying changes in ambulation in the open-field test. Moreover, the repeated administration (14 days) of the hydroalcoholic extract of R. officinalis by p.o. route also produced an antidepressant-like effect in the TST (100-300 mg/kg). The pretreatment of mice with p-chlorophenylalanine (PCPA, 100 mg/kg, i.p., an inhibitor of serotonin synthesis, for 4 consecutive days), NAN-190 (0.5 mg/kg, i.p., a 5-HT(1A) receptor antagonist), ketanserin (5 mg/kg, i.p., a 5-HT(2A) receptor antagonist), 1-(m-chlorophenyl) biguanide (mCPBG, 10 mg/kg, i.p., a 5-HT(3) receptor agonist), prazosin (1 mg/kg, i.p., an alpha(1-)adrenoceptor antagonist), SCH23390 (0.05 mg/kg, s.c., a dopamine D(1) receptor antagonist) or sulpiride (50 mg/kg, i.p., a dopamine D(2) receptor antagonist), but not yohimbine (1 mg/kg, i.p., an alpha(2-)adrenoceptor antagonist) was able to reverse the anti-immobility effect of the extract (10 mg/kg, p.o.) in the TST. The combination of MDL72222, (0.1 mg/kg, i.p., a 5-HT(3) receptor antagonist) with a sub-effective dose of the extract of R. officinalis (1 mg/kg, p.o.) produced an anti-immobility effect in the TST. The results suggest that the antidepressant action of the extract of R. officinalis is mediated by an interaction with the monoaminergic system and that this plant should be further investigated as an alternative therapeutic approach for the treatment of depression.read more
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Journal ArticleDOI
A novel insight on an ancient aromatic plant: The rosemary (Rosmarinus officinalis L.)
Regiane Ribeiro-Santos,Regiane Ribeiro-Santos,Regiane Ribeiro-Santos,D. Carvalho-Costa,D. Carvalho-Costa,Carlos Cavaleiro,Helena S. Costa,Helena S. Costa,Tânia Gonçalves Albuquerque,Tânia Gonçalves Albuquerque,Maria Conceição Castilho,Fernando Ramos,Nathália Ramos de Melo,Nathália Ramos de Melo,Ana Sanches-Silva,Ana Sanches-Silva +15 more
TL;DR: An extensive bibliographic review on rosemary was carried out, including its main uses, components (both nutrients and bioactive), biological activities, interactions with drugs and potential applications, which reveals a great amount of vitamins and minerals.
Journal ArticleDOI
Advances in phenolic compounds analysis of aromatic plants and their potential applications
D. Carvalho Costa,D. Carvalho Costa,Helena S. Costa,Helena S. Costa,T. Gonçalves Albuquerque,T. Gonçalves Albuquerque,F. Ramos,Maria Conceição Castilho,Ana Sanches-Silva,Ana Sanches-Silva +9 more
TL;DR: A review on the main uses of aromatic plants generally recognized as safe (GRAS) and overviews the extraction, purification and analytical methods used to determine phenolics in these food matrices is presented in this paper.
Journal ArticleDOI
Rosmarinus Officinalis Leaves as a Natural Source of Bioactive Compounds
Isabel Borrás-Linares,Zorica Stojanović,Rosa Quirantes-Piné,David Arráez-Román,Jaroslava Švarc-Gajić,Alberto Fernández-Gutiérrez,Antonio Segura-Carretero +6 more
TL;DR: The composition of different extracts of rosemary leaves collected from different geographical zones of Serbia was studied and rosemary samples from Sokobanja presented the highest levels in flavonoids and other compounds such as carnosol, rosmaridiphenl, rosmadial, ro'smarinic acid, and carnosic acid.
Journal ArticleDOI
Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L.
Daniele G. Machado,Mauricio P. Cunha,Vivian B. Neis,Grasiela O. Balen,André R.S. Colla,Luis E.B. Bettio,Ágatha Oliveira,Francis L. Pazini,Juliana Bastos Dalmarco,Edésio Luiz Simionatto,Moacir Geraldo Pizzolatti,Ana Lúcia S. Rodrigues +11 more
TL;DR: It is suggested that carnosol and betulinic acid could be responsible for the anti-immobility effect of extracts from R. officinalis, and the effects in the tail suspension test are specific.
Journal ArticleDOI
Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation
TL;DR: First evidence to contribute to the understanding of molecular mechanism behind the anti-depressant effect of R. officinalis is contributed, with results concordant with decreasing immobility time in TST and regulation of several neurotransmitters and gene expression in mice brain.
References
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Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
Journal ArticleDOI
The tail suspension test: A new method for screening antidepressants in mice
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Journal ArticleDOI
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TL;DR: A neurobiologic understanding of depression also requires identification of the genes that make individuals vulnerable or resistant to the syndrome, and advances will fundamentally improve the treatment and prevention of depression.
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Assessing antidepressant activity in rodents: recent developments and future needs
TL;DR: This review focuses on recent findings regarding some of the most widely employed animal models used currently to predict antidepressant potential, and emphasis is placed on recent modifications to such paradigms that have increased their utility and reliability.
Journal ArticleDOI
The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.
TL;DR: The tail suspension test is a useful test for assessing the behavioural effects of antidepressant compounds and other pharmacological and genetic manipulations relevant to depression.
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