Luis E.B. Bettio

TL;DR: Non‐invasive strategies such as caloric restriction, physical exercise, and environmental enrichment have been shown to counteract many of the age‐induced alterations in hippocampal signalling, structure, and function, and such approaches may have therapeutic value in counteracting the deleterious effects of aging and protecting the brain against age‐associated neurodegenerative processes.

TL;DR: The results suggest that the antidepressant action of the extract of R. officinalis is mediated by an interaction with the monoaminergic system and that this plant should be further investigated as an alternative therapeutic approach for the treatment of depression.

TL;DR: The results indicated the antidepressant-like effect of the ethanolic extract of S. molle in the tail suspension test may be dependent on the presence of rutin that likely exerts its antidepressant- like effect by increasing the availability of serotonin and noradrenaline in the synaptic cleft.

TL;DR: Findings indicate that, despite presenting distinct features, there are several similarities between the neurobiological alterations that lead to MDD and neurodegeneration in AD, PD, and HD, and the current evidence regarding the effectiveness of common antidepressant therapies for the treatment of MDD in patients with these Neurodegenerative diseases is summarized.

TL;DR: In this study, zinc chloride was given alone or in combination with different classes of antidepressants by oral route to mice and the behavioral response in the tail suspension test (TST), a predictive test of antidepressant action, was investigated, suggesting that an improvement in the response to the antidepressant therapy occurs when zinc is combined with differentclasses of antidepressants.