M
Maxim N. Zhmak
Researcher at Russian Academy of Sciences
Publications - 58
Citations - 1179
Maxim N. Zhmak is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Nicotinic acetylcholine receptor & Nicotinic agonist. The author has an hindex of 16, co-authored 58 publications receiving 1058 citations.
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Journal ArticleDOI
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.
Patrick H.N. Celie,Igor E. Kasheverov,Dmitry Y. Mordvintsev,Ron C. Hogg,Pim van Nierop,René van Elk,Sarah E. van Rossum-Fikkert,Maxim N. Zhmak,Daniel Bertrand,Victor I. Tsetlin,Titia K. Sixma,August B. Smit +11 more
TL;DR: The structure at a resolution of 2.4 Å of α-Ctx PnIA (A10L D14K), a potent blocker of the α7-nAChR, bound with high affinity to acetylcholine binding protein (AChBP), the prototype for the ligand-binding domains of the nA ChR superfamily is presented.
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Differential involvement of α4β2, α7 and α9α10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro.
Lyudmyla Koval,Olena Lykhmus,Maxim N. Zhmak,Alexey Yu. Khruschov,Victor I. Tsetlin,Elena Magrini,Antonella Viola,Alexander I. Chernyavsky,Jing Qian,Sergei A. Grando,Sergei Komisarenko,Maryna Skok +11 more
TL;DR: It is concluded that α7 nA ChR fulfills inhibitory CD40-related mitogenic function, α4β2 nAChR produces a stimulatory IgM-related effect, while α9α10 nAchR is a "reserve" receptor, which partly compensates the absence of α7nAChr in α7(-/-) cells.
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Recombinant expression, synthesis, purification, and solution structure of arenicin.
Tatiana V. Ovchinnikova,Zakhar O. Shenkarev,Kirill D. Nadezhdin,Sergey V. Balandin,Maxim N. Zhmak,Irina A. Kudelina,Ekaterina I. Finkina,V. N. Kokryakov,Alexander S. Arseniev +8 more
TL;DR: The results suggest that arenicins are membrane active peptides and point to possible mechanism of their selectivity toward bacterial cells.
Journal ArticleDOI
Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction.
TL;DR: It is concluded that cholinergic regulation in mitochondria is realized through multiple nicotinic receptor subtypes, which control various pathways inducing mitochondrial type of apoptosis.
Journal ArticleDOI
NMR spatial structure of α-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors1
Innokenty V. Maslennikov,Zakhar O. Shenkarev,Maxim N. Zhmak,Vadim T. Ivanov,Christoph Methfessel,Victor I. Tsetlin,Alexander S. Arseniev +6 more
TL;DR: When depicted with opposite directions of the polypeptide chains, the ImI helix and the tip of the central loop of long chain snake neurotoxins demonstrate a common scaffold and similar positioning of the functional side chains, both of these structural elements appearing essential for binding to the neuronal nAChRs.