Pim van Nierop

TL;DR: It is shown that synaptic genes are exceptionally well conserved and less tolerant to mutations than other genes, and among de novo variants associated with neurodevelopmental disorders, including schizophrenia.

TL;DR: The structure at a resolution of 2.4 Å of α-Ctx PnIA (A10L D14K), a potent blocker of the α7-nAChR, bound with high affinity to acetylcholine binding protein (AChBP), the prototype for the ligand-binding domains of the nA ChR superfamily is presented.

TL;DR: Comparison of the crystal structure of a remote homolog of AChBP from Bulinus truncatus reveals both the conserved structural scaffold and the sites of variation in this receptor family, which will be valuable for improving structure-function studies of ligand-gated ion channel receptors.

TL;DR: A comprehensive quantitative proteomics study on human hippocampus tissue involving all Braak stages to assess changes in protein abundance over the various stages of Alzheimer's disease (AD).

TL;DR: An important role for the extracellular matrix in causing early memory loss in Alzheimer’s disease is indicated by the early increase in amyloid-β levels in APP/PS1 mice at three months of age, which coincides with a robust and significant upregulation of several protein components of the Extracellular Matrix in hippocampal synaptosome preparations.