M
Maxime G. P. Buffat
Researcher at University of Manchester
Publications - 4
Citations - 503
Maxime G. P. Buffat is an academic researcher from University of Manchester. The author has contributed to research in topics: Metathesis & Hydroboration. The author has an hindex of 3, co-authored 4 publications receiving 489 citations.
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Approaches to 3,4,5-substituted piperidines via 1,2,5,6-tetrahydropyridines prepared by ring-closing metathesis
TL;DR: In this paper, a ring-closing metathesis (RCM) was used to synthesize 3-alkoxymethyl-1,2,5,6-tetrahydropyridines with protected amino and cyclobutyl substituents.
Journal ArticleDOI
Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M1) receptor agonists: a novel M1 allosteric modulator
Kenneth J. Broadley,Maxime G. P. Buffat,Erica S. Burnell,Robin H. Davies,Xavier Moreau,Stephen Snee,Eric J. Thomas +6 more
TL;DR: The bicyclic system with a 2-furyl substituent at C2 was identified as an important target and the (1RS,2SR,6SR) nonan-8-ones with substituents at C1 that could facilitate C2 deprotonation were unstable with respect to oxazolidinone ring-opening and this restricted both the synthetic approach and choice of 2-heteroaryl substituENT.