Showing papers in "Tetrahedron in 2016"

TL;DR: This review describes the general features and applications of CuAAC in organic synthesis (CuAAC-OS), highlighting the suitability of this kind of reaction for peptides, nucleotides, small molecules, supramolecular structures, and polymers among others.

TL;DR: Analysis of the structure–activity relationship of these compounds have led to the facile production of inexpensive QACs that display ∼1 μM MIC against a suite of bacteria, and furthermore do not appear to trigger bacterial resistance systems in methicillin-resistant Staphylococcus aureus (MRSA).

TL;DR: Co-culturing the fungal endophyte Chaetomium sp.

TL;DR: Recent trends and the future prospects of deploying narrower spectrum antibiotics coupled with rapid diagnostics are reviewed and the theoretical advantages and limitations of this emerging approach to controlling bacterial infectious diseases are discussed.

TL;DR: In this paper, a chemical sensor containing triphenylamine and benzothiadiazole for cyanide anions detection was designed and synthesized, whose structural feature is a donor-acceptor-donor (D-A-D) molecular configuration, which is substituted with a dicyanovinyl group served as a sensing unit.

TL;DR: In this article, the [3+2] cycloaddition reactions of the nitrile ylide (NY) with ethylene and with dicyanoethylene (DCE) have been studied using the Molecular Electron Density Theory through DFT calculations at the MPWB1K/6-31G(d) level.

TL;DR: In this article, the structures of these isolates including their absolute configurations were assigned by spectroscopic and computational methods, in particular, the structure of 1, 3 and 12 were confirmed by single crystal X-ray diffraction data.

TL;DR: In this article, a bioassay-guided fractionation and chromatographic separation of a deep-sea fungus Aspergillus versicolor resulted in the isolation of 22 phenolic compounds, of which six were new natural products namely aspergilols A-F (1, 6).

TL;DR: In this article, a colorimetric chemosensor for detecting both Cu2+ and Cr3+ ions was designed and synthesized as a visible test strip for Cu2+, and the sensing abilities of sensor 1 were evaluated in real water samples.

TL;DR: The advances made in chemistry during the last 70 years are excellently illustrated by the development of the industrial synthesis of vitamin A, a diterpene crucial in preventing premature death and visual problems as mentioned in this paper.

TL;DR: Direct radical oxyphosphorylation of styrenes with diarylphosphine oxides and dialkyl phosphites mediated by Mn(OAc) 3 is described in this paper.

TL;DR: A colorimetric and fluorescence turn-on cyanide probe, including coumarin-thiazole and imine (azomethine) group, has been designed and synthesized as mentioned in this paper.

TL;DR: Eight new linear peptides A–H were isolated from a culture broth of the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020 and showed strong antifouling activity against Bugula neritina larvae settlement and weak cytotoxicity towards human leukemia HL-60 or K562 cell line.

TL;DR: In this article, the heterocyclodehydration and iodocyclization of readily available 1-mercapto-3-yn-2-ols was performed in a deep eutectic solvent (DES), that is, ChCl/Gly (1:2 molar ratio; ChCl=choline chloride, Gly=glycerol), as a non-conventional green solvent.

TL;DR: In this paper, the authors achieved regioselectivity in transition metal-catalyzed direct C-H (hetero)arylation reactions of hetero-arenes with one heteroatom through the use of removable protecting/blocking substituents or traceless directing groups.

TL;DR: This work reports the first method of coupling of aryl acetaldehydes on imidazo[1,2-a]pyridine system via double-oxidative cross-dehydogenative process and provides a straightforward, high yielding and one-pot approach towards the synthesis of C-3 dicarbonylatedImidazoheterocycles without prior activation of C(sp2)-H or a base.

TL;DR: The goal of this review is to collect the major developments in organocatalytic dynamic kinetic resolution reported since the beginning of 2011, well illustrating that the synthetic scope of these powerful processes allowing the resolution of racemic compounds with up to 100% yield has been widely expanded in the last five years.

TL;DR: In this paper, 1-methyl, 1-triisopropylsilyl-, and 1-benzylindoles are carboxylated under CO2 pressure with the aid of 1.0molar equiv of Me2AlCl to give 1-substituted indole-3-carboxylic acids in good to excellent yields.

TL;DR: In this paper, the design, structural characterization and potential medical application of novel 1,2,4-oxadiazole and trifluoromethylpyridine derivatives are described.

TL;DR: A method for acylation for heteroarenes under metal-free conditions has been described using NCS as an additive and TBHP as an oxidant and this strategy provides an efficient, mild and inexpensive method.