M
Maxime P. Look
Researcher at Erasmus University Medical Center
Publications - 117
Citations - 12418
Maxime P. Look is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: Breast cancer & Tamoxifen. The author has an hindex of 57, co-authored 117 publications receiving 11784 citations. Previous affiliations of Maxime P. Look include Erasmus University Rotterdam & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer.
Yixin Wang,Jan Klijn,Yi Zhang,Anieta M. Sieuwerts,Maxime P. Look,Fei Yang,Dmitri Talantov,Mieke Timmermans,Marion E. Meijer-van Gelder,Jack X. Yu,Tim Jatkoe,Els M.J.J. Berns,David Atkins,John A. Foekens +13 more
TL;DR: The ability to identify patients who have a favourable prognosis could, after independent confirmation, allow clinicians to avoid adjuvant systemic therapy or to choose less aggressive therapeutic options.
Journal ArticleDOI
Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients.
Maxime P. Look,Wim L. J. van Putten,Michael J. Duffy,Nadia Harbeck,Ib Jarle Christensen,Christoph Thomssen,Ronald E. Kates,Frédérique Spyratos,Mårten Fernö,Serenella Eppenberger-Castori,C. G. J. Fred Sweep,Kurt Ulm,J. P. Peyrat,Pierre-Marie Martin,Henri Magdelenat,Nils Brünner,Catherine Duggan,Björn W. Lisboa,Pär-Ola Bendahl,Véronique Quillien,A Daver,Gabriel Ricolleau,Marion E. Meijer-van Gelder,Peggy Manders,W. Edward Fiets,Marinus A. Blankenstein,Philippe Broët,Sylvie Romain,Günter Daxenbichler,Gudrun Windbichler,Tanja Cufer,Simona Borštnar,Willy Kueng,Louk V.A.M. Beex,Jan G. M. Klijn,Niall O'Higgins,Urs Eppenberger,Fritz Jänicke,Manfred Schmitt,John A. Foekens +39 more
TL;DR: For patients with lymph node-negative breast cancer, uPA and PAI-1 measurements in primary tumors may be especially useful for designing individualized treatment strategies.
Journal Article
The Urokinase System of Plasminogen Activation and Prognosis in 2780 Breast Cancer Patients
J.A. Foekens,H. A. Peters,Maxime P. Look,H. Portengen,Manfred Schmitt,M. D. Kramer,Nils Brünner,Fritz Jänicke,M.E. Meijer-van Gelder,S. C. Henzen-Logmans,W. L. J. Van Putten,J.G.M. Klijn +11 more
TL;DR: It is concluded that several components of the uPA system are potential predictors of RFS and OS in patients with primary invasive breast cancer and may benefit from targeted therapies that are currently being developed.
Journal ArticleDOI
Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer
John A. Foekens,Anieta M. Sieuwerts,Marcel Smid,Maxime P. Look,Vanja de Weerd,Antonius W. M. Boersma,Jan G. M. Klijn,Erik A.C. Wiemer,John W.M. Martens +8 more
TL;DR: This work connects four miRNAs to breast cancer progression and to several distinct biological processes involved therein.
Journal ArticleDOI
Molecular Classification of Tamoxifen-Resistant Breast Carcinomas by Gene Expression Profiling
Maurice P.H.M. Jansen,John A. Foekens,Iris L. van Staveren,Maaike J.M. Dirkzwager-Kiel,Kirsten Ritstier,Maxime P. Look,Marion E. Meijer-van Gelder,Anieta M. Sieuwerts,H. Portengen,Lambert C. J. Dorssers,Jan G. M. Klijn,Els M.J.J. Berns +11 more
TL;DR: Data show that gene expression profiling can be used to discriminate between breast cancer patients with progressive disease and objective response to tamoxifen, and additional studies are needed to confirm if the predictive signature might allow identification of individual patients who could benefit from other endocrine therapies.