M
Maximilian G. Burger
Researcher at University of Basel
Publications - 12
Citations - 620
Maximilian G. Burger is an academic researcher from University of Basel. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor. The author has an hindex of 7, co-authored 10 publications receiving 401 citations. Previous affiliations of Maximilian G. Burger include University Hospital of Basel.
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Journal ArticleDOI
It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration.
Andrea Grosso,Maximilian G. Burger,Alexander Lunger,Dirk J. Schaefer,Andrea Banfi,Nunzia Di Maggio +5 more
TL;DR: The current state of knowledge on the molecular cross-talk between angiogenesis and osteogenesis is reviewed and the role of VEGF in coupling these two processes is focused on and how V EGF dose can control the outcome.
Journal ArticleDOI
Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine.
Mikaël M. Martino,Sime Brkic,Emmanuela Bovo,Maximilian G. Burger,Dirk J. Schaefer,Thomas Wolff,Lorenz Gürke,Priscilla S. Briquez,Hans M. Larsson,Roberto Gianni-Barrera,Jeffrey A. Hubbell,Jeffrey A. Hubbell,Jeffrey A. Hubbell,Andrea Banfi +13 more
TL;DR: The therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, are discussed and an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors are provided.
Journal ArticleDOI
PDGF-BB regulates splitting angiogenesis in skeletal muscle by limiting VEGF-induced endothelial proliferation
Roberto Gianni-Barrera,Roberto Gianni-Barrera,Roberto Gianni-Barrera,A. Butschkau,Andrea Uccelli,Andrea Uccelli,A. Certelli,A. Certelli,P. Valente,P. Valente,M. Bartolomeo,M. Bartolomeo,E. Groppa,E. Groppa,E. Groppa,Maximilian G. Burger,Maximilian G. Burger,Ruslan Hlushchuk,Michael Heberer,Michael Heberer,Dirk J. Schaefer,Lorenz Gürke,Valentin Djonov,Brigitte Vollmar,Andrea Banfi,Andrea Banfi +25 more
TL;DR: PDGF-BB co-expression prevents V EGF-induced aberrant angiogenesis by modulating VEGF-R2 signaling and endothelial proliferation, thereby limiting the degree of circumferential enlargement and enabling efficient completion of vascular splitting into normal capillary networks despite high VEGf doses.
Journal ArticleDOI
Therapeutic vascularization in regenerative medicine.
Roberto Gianni-Barrera,Nunzia Di Maggio,Ludovic Melly,Maximilian G. Burger,Edin Mujagic,Lorenz Gürke,Dirk J. Schaefer,Andrea Banfi +7 more
TL;DR: Recent insights into the mechanisms that regulate vessel stabilization and the switch between normal and aberrant vascular growth after VEGF delivery are presented, to identify novel molecular targets that may improve both safety and efficacy of therapeutic angiogenesis.
Journal ArticleDOI
Long-term safety and stability of angiogenesis induced by balanced single-vector co-expression of PDGF-BB and VEGF164 in skeletal muscle.
Roberto Gianni-Barrera,Roberto Gianni-Barrera,Maximilian G. Burger,Maximilian G. Burger,Thomas Wolff,Thomas Wolff,Michael Heberer,Michael Heberer,Dirk J. Schaefer,Lorenz Gürke,Edin Mujagic,Edin Mujagic,Andrea Banfi,Andrea Banfi +13 more
TL;DR: It was found that co-expression of the pericyte-recruiting factor PDGF-BB at a fixed ratio with V EGF from a single bicistronic vector ensured normal angiogenesis despite heterogeneous high VEGF levels.