M
Megan Hames
Researcher at National Institutes of Health
Publications - 3
Citations - 652
Megan Hames is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Lung cancer & Gene expression profiling. The author has an hindex of 3, co-authored 3 publications receiving 601 citations.
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Journal ArticleDOI
Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival.
Maria Teresa Landi,Tatiana Dracheva,Melissa Rotunno,Jonine D. Figueroa,Huaitian Liu,Abhijit Dasgupta,Felecia E. Mann,Junya Fukuoka,Megan Hames,Andrew W. Bergen,Sharon E. Murphy,Ping Yang,Angela Cecilia Pesatori,Dario Consonni,Pier Alberto Bertazzi,Sholom Wacholder,Joanna H. Shih,Neil E. Caporaso,Jin Jen +18 more
TL;DR: This work provides insight into the smoking-related mechanisms of lung neoplasia, and shows that the very mitotic genes known to be involved in cancer development are induced by smoking and affect survival.
Journal ArticleDOI
The use of genetic markers to identify lung cancer in fine needle aspiration samples.
Rajbir K. Gill,Madeline Vazquez,Arin Kramer,Megan Hames,Lijuan Zhang,Kerstin Heselmeyer-Haddad,Thomas Ried,Konstantin Shilo,Claudia I. Henschke,David F. Yankelevitz,Jin Jen +10 more
TL;DR: A set of only four genetic markers can distinguish the neoplastic state of lung lesion using small samples obtained through computed tomography–guided fine needle aspiration, and confirmed in 15 of 16 lung cancer cases regardless of tumor subtype, stage, or size.
Journal ArticleDOI
Inactivation of LLC1 gene in nonsmall cell lung cancer.
Kyeong Man Hong,Sei Hoon Yang,Sinchita Roy Chowdhuri,Audrey Player,Megan Hames,Junya Fukuoka,Junya Fukuoka,Daoud Meerzaman,Tatiana Dracheva,Zhifu Sun,Ping Yang,Jin Jen +11 more
TL;DR: Results suggest that inactivation of LLC1 by means of promoter methylation is a frequent event in nonsmall cell lung cancer and may play a role in lung tumorigenesis.