M
Melanie A. Woodin
Researcher at University of Toronto
Publications - 60
Citations - 3582
Melanie A. Woodin is an academic researcher from University of Toronto. The author has contributed to research in topics: Inhibitory postsynaptic potential & Excitatory postsynaptic potential. The author has an hindex of 29, co-authored 57 publications receiving 3048 citations. Previous affiliations of Melanie A. Woodin include University of California, Berkeley & University of Calgary.
Papers
More filters
Journal ArticleDOI
Coincident Pre- and Postsynaptic Activity Modifies GABAergic Synapses by Postsynaptic Changes in Cl− Transporter Activity
TL;DR: It is reported that, in both hippocampal cultures and acute hippocampal slices, repetitive postsynaptic spiking within 20 ms before and after the activation of GABAergic synapses also led to a persistent change in synaptic strength.
Journal ArticleDOI
Neurons are recruited to a memory trace based on relative neuronal excitability immediately before training
Adelaide P. Yiu,Valentina Mercaldo,Chen Yan,Blake A. Richards,Asim J. Rashid,Hwa-Lin Liz Hsiang,Jessica C. Pressey,Vivek Mahadevan,Matthew M Tran,Steven A. Kushner,Melanie A. Woodin,Paul W. Frankland,Sheena A. Josselyn +12 more
TL;DR: The results indicate that neuronal memory allocation is based on relative neuronal excitability immediately before training, and that neurons with increased CREB are critical components of the memory trace.
Journal ArticleDOI
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.
Mona Meyer,Jüri Reimand,Xiaoyang Lan,Renee Head,Xueming Zhu,Michelle Kushida,Jane Bayani,Jessica C. Pressey,Anath C. Lionel,Ian D. Clarke,Michael D. Cusimano,Jeremy A. Squire,Stephen W. Scherer,Mark Bernstein,Melanie A. Woodin,Gary D. Bader,Peter B. Dirks +16 more
TL;DR: It is predicted that integration of functional and genomic analysis at a clonal level will be essential for understanding evolution and therapeutic resistance of human cancer, and will lead to the discovery of novel driver mechanisms and clone-specific cancer treatment.
Journal ArticleDOI
Single cell derived clonal analysis of human glioblastoma links functional and genomic heterogeneity.
Peter B. Dirks,Mona Meyer,Jüri Reimand,Xiaoyang Lan,Renee Head,Xueming Zhu,Michelle Kushida,Jane Bayani,Jessica C. Pressey,Anath C. Lionel,Ian D. Clarke,Michael D. Cusimano,Jeremy A. Squire,Stephen W. Scherer,Mark Bernstein,Melanie A. Woodin,Gary D. Bader +16 more
TL;DR: The results suggest that functional clonal profiling used to identify tumorigenic and drug resistant tumor clones will lead to the discovery of new GBM clone-specific treatment strategies.
Journal ArticleDOI
Role of activity-dependent regulation of neuronal chloride homeostasis in development.
TL;DR: Evidence shows how both activity and neurotrophic factors can affect GABAergic transmission in the mammalian central nervous system through their effects on the neuron-specific chloride-extruding transporter KCC2, profoundly affecting the development and function of neuronal networks.