Melchor Sanchez-Martinez

TL;DR: It is described that brain metastatic cells induce and maintain the co-option of a pro-metastatic program driven by signal transducer and activator of transcription 3 (STAT3) in a subpopulation of reactive astrocytes surrounding metastatic lesions, and that a safe and orally bioavailable treatment that inhibits STAT3 exhibits significant antitumor effects in patients with advanced systemic disease that included brain metastasis.

TL;DR: In silico analysis focusing on the molecular docking and dynamic simulation of the putative interactions between metformin and SIRT1, it is confirmed that the net biochemical effect of met formin and other biguanides such as a phenformin was to improve the catalytic efficiency of SIRT 1 operating in conditions of low NAD+ in vitro.

TL;DR: A systematic chemoinformatics approach coupled to experimental validation reveals that metformin might directly regulate the biological machinery of aging by targeting core chromatin modifiers of the epigenome.

TL;DR: The prevention ofSTAT3 nuclear translocation, the blockade of the binding of activated STAT3 to its consensus DNA sequence, and the suppression of STAT3-directed transcriptional activity confirmed silibinin as a direct STAT3i, a promising lead for designing new, more effectiveSTAT3i.

TL;DR: In this paper, the authors employed a phenotypic drug discovery approach coupled to mechanism-of-action profiling and target deconvolution to identify phenolic components of extra virgin olive oil (EVOO) capable of suppressing the functional traits of cancer stem cells in breast cancer (BC).