Melissa J Sammy

TL;DR: These studies support the 'mitochondrial paradigm' for the development of disease susceptibility, and show that the mtDNA modulates cellular bioenergetics, mitochondrial ROS generation and susceptibility to cardiac stress.

TL;DR: The potential role for mitochondrial genetics and function in determining CVD susceptibility is considered from the standpoint that the original features that molded cellular function were based upon mitochondrial–nuclear relationships established millions of years ago and were likely refined during prehistoric environmental selection events that today, are largely absent.

TL;DR: Results demonstrate that nuclear-mitochondrial genetic background combination significantly alters metabolic efficiency and body composition and provides a new framework for understanding complex genetic disease susceptibility.

TL;DR: Differences in mitochondrial bioenergetics and mtDNA damage associated with maternal ancestry may contribute to endothelial dysfunction and vascular disease.