M
Melissa M. Guimarães
Researcher at Universidade Federal de Minas Gerais
Publications - 18
Citations - 261
Melissa M. Guimarães is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Dopaminergic & Medicine. The author has an hindex of 9, co-authored 13 publications receiving 248 citations. Previous affiliations of Melissa M. Guimarães include Faculdade de Medicina da Universidade Federal de Minas Gerais.
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Journal ArticleDOI
Coronary Artery Bypass Surgery Provokes Alzheimer's Disease-Like Changes in the Cerebrospinal Fluid
András Palotás,Helton José Reis,Gábor Bogáts,Barna Babik,Mihály Racsmány,Mihály Racsmány,Linda Engvau,Eva Kecskeméti,Anna Juhász,Luciene B. Vieira,Antônio Lúcio Teixeira,Marat A Mukhamedyarovi,Albert A. Rizvanov,Albert A. Rizvanov,Albert A. Rizvanov,Mehmet Emir Yalvaç,Melissa M. Guimarães,Cláudia N. Ferreira,Andrey L. Zefirov,Andrey P. Kiyasov,Lan Wang,Zoltán Janka,János Kálmán +22 more
TL;DR: Findings clearly demonstrate post-surgical cognitive impairment associated with changes in biomarkers similar to that seen in Alzheimer's disease, suggesting a unifying pathognomic factor between the two disorders.
Journal ArticleDOI
Familial suicide behaviour: association with probands suicide attempt characteristics and 5-HTTLPR polymorphism
Humberto Correa,A. C. Campi-Azevedo,L. De Marco,M. M. Viana,Melissa M. Guimarães,Evandro Costa,Débora Marques de Miranda,Marco Aurélio Romano-Silva +7 more
TL;DR: There is compelling evidence that a serotonergic dysfunction may play a major role in suicide behaviour and it has been demonstrated that suicide is, at least partially, genetically determined, Thus, the serotonin‐related genes are the major candidates.
Journal ArticleDOI
Nucleoplasmic calcium buffering sensitizes human squamous cell carcinoma to anticancer therapy
Lídia M. Andrade,Jony Marques Geraldo,Osvaldo Xavier Gonçalves,Miguel T. T. Leite,Anderson M. Catarina,Melissa M. Guimarães,Adriana F. Paes Leme,Sami Yokoo,Carlos Roberto Machado,Matheus Andrade Rajão,Sandhra M. Carvalho,Dawidson Assis Gomes,Carla J. Aguiar,Elaine Maria de Souza Fagundes,Carlos L. Zani,Rodrigo R. Resende,Olindo Assis Martins Filho,Maria de Fátima Leite,Mucurí. Diamantina,MG, Brazil,Immunology. Belo Horizonte, Mg, Brazil,Biophysics. Belo Horizonte, Mg, Brazil +20 more
TL;DR: Nuclear Ca 2+ buffering sensitizes human squamous cell carcinoma to X-rays irradiation treatment and prevents the increase of the radioresistance-related biomarker ADAM-17 expression and EGFR activation induced by irradiation.
Journal ArticleDOI
Is DARPP-32 a potential therapeutic target?
Helton José Reis,Daniela V.F. Rosa,Melissa M. Guimarães,Bruno R. Souza,Alexandre Guimarães de Almeida Barros,Flávio Juliano Pimenta,Renan P. Souza,Karen C.L. Torres,Marco Aurélio Romano-Silva +8 more
TL;DR: DARPP-32 has also been identified in non-neuronal tissues and its level of expression has been associated with the malignant level of some types of cancer, via modulation of cell survival and differentiation.
Journal ArticleDOI
Disease-specific expression of the serotonin-receptor 5-HT2C in natural killer cells in Alzheimer's dementia
Luiza da Conceição Amorim Martins,Natalia Pessoa Rocha,Karen C.L. Torres,Rodrigo Ribeiro dos Santos,Giselle Sabrina França,Edgar Nunes de Moraes,Marat A. Mukhamedyarov,Andrey L. Zefirov,Albert A. Rizvanov,Andrey P. Kiyasov,Luciene B. Vieira,Melissa M. Guimarães,Mehmet Emir Yalvaç,Antônio Lúcio Teixeira,M.A.C. Bicalho,Zoltán Janka,Marco Aurélio Romano-Silva,András Palotás,Helton José Reis +18 more
TL;DR: The dopaminergic and serotonergic systems in AD are characterized, which are also markedly disrupted along with the hallmark acetyl-choline dysfunction, and may serve as potential biomarkers for less invasive and early diagnostic purposes as well.