M
Melissa M. Rundle
Researcher at Washington University in St. Louis
Publications - 22
Citations - 3026
Melissa M. Rundle is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 12 publications receiving 2637 citations.
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Journal ArticleDOI
The default mode network and self-referential processes in depression
Yvette I. Sheline,M Deanna,Joseph L. Price,Melissa M. Rundle,S. Neil Vaishnavi,Abraham Z. Snyder,Mark A. Mintun,Suzhi Wang,Rebecca S. Coalson,Marcus E. Raichle +9 more
TL;DR: Depression is characterized by both stimulus-induced heightened activity and a failure to normally down-regulate activity broadly within the DMN, and these findings provide a brain network framework within which to consider the pathophysiology of depression.
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Regional aerobic glycolysis in the human brain
S. Neil Vaishnavi,Andrei G. Vlassenko,Melissa M. Rundle,Abraham Z. Snyder,Mark A. Mintun,Marcus E. Raichle +5 more
TL;DR: Striking regional variations in aerobic glycolysis in the normal human brain provide an opportunity to explore how brain systems differentially use the diverse cell biology of glucose in support of their functional specializations in health and disease.
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Altered Emotional Interference Processing in Affective and Cognitive-Control Brain Circuitry in Major Depression
Christina L. Fales,M Deanna,Melissa M. Rundle,Mark A. Mintun,Abraham Z. Snyder,Jonathan D. Cohen,Jose Mathews,Yvette I. Sheline +7 more
TL;DR: These results suggest multiple sources of dysregulation in emotional and cognitive control circuitry in depression, implicating both top-down and bottom-up dysfunction.
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Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression
Christina L. Fales,M Deanna,Melissa M. Rundle,Mark A. Mintun,Jose Mathews,Abraham Z. Snyder,Yvette I. Sheline +6 more
TL;DR: It is suggested that antidepressant treatment increases DLPFC under-activity during cognitive tasks that include emotional interference, which is similar to normal activity after treatment with SSRI.
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Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain
TL;DR: These observations support the hypothesis that an increase in the NADH/NAD(+) ratio activates signaling pathways to selectively increase CBF in the physiologically stimulated brain regions.