M
Meng Meng
Researcher at Peking University
Publications - 5
Citations - 188
Meng Meng is an academic researcher from Peking University. The author has contributed to research in topics: Bioavailability & Surface plasmon resonance. The author has an hindex of 5, co-authored 5 publications receiving 178 citations.
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Journal ArticleDOI
pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A
TL;DR: The potential of pH-sensitive nanoparticles for the oral delivery of CyA was confirmed and in vitro release experiments revealed that the nanoparticles exhibited perfect pH-dependant release profiles.
Journal ArticleDOI
Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes.
Meng Meng,Yu Liu,Yi-Bo Wang,Jiancheng Wang,Hua Zhang,Xueqing Wang,Xuan Zhang,Wan-Liang Lu,Qiang Zhang +8 more
TL;DR: It is suggested that cationic liposomes may be a potential sustained-release delivery system for parenteral administration of hydrophilic proteins or peptides with low isoelectric point to prolong efficacy and improve bioavailability.
Journal ArticleDOI
Comprehensive studies on the interactions between chitosan nanoparticles and some live cells
TL;DR: It is demonstrated that chitosan nanoparticles (CS-NP) induce strong alterations in the distribution of membrane proteins, fluidity of membrane lipids, and general membrane structure, which supports the idea that CS-NP is an effective and safe carrier for oral drug delivery.
Journal ArticleDOI
Effects of pH-sensitive nanoparticles prepared with different polymers on the distribution, adhesion and transition of Rhodamine 6G in the gut of rats.
Wu Cuishuan,Xueqing Wang,Meng Meng,Ming-Guang Li,Hua Zhang,Xuan Zhang,Jiancheng Wang,Tao Wu,Wen-hui Nie,Qiang Zhang +9 more
TL;DR: P pH-sensitive nanoparticles seem favourable for drug absorption and it is important to choose the proper materials to obtain the suitable characteristics for the oral pH- sensitive nanoparticles.
Journal Article
Preparation of cyclosporine A pH sensitive nanoparticles and oral pharmacokinetics in rats
TL;DR: CyA-S100 nanoparticles was shown to significantly improve the oral bioavailability of CyA compared with Neoral microemulsion (P < 0.05), and the potential of pH-sensitive nanoparticles for the oral delivery ofCyA was confirmed.