Journal ArticleDOI
Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes.
Meng Meng,Yu Liu,Yi-Bo Wang,Jiancheng Wang,Hua Zhang,Xueqing Wang,Xuan Zhang,Wan-Liang Lu,Qiang Zhang +8 more
TLDR
It is suggested that cationic liposomes may be a potential sustained-release delivery system for parenteral administration of hydrophilic proteins or peptides with low isoelectric point to prolong efficacy and improve bioavailability.About:
This article is published in Journal of Controlled Release.The article was published on 2008-06-04. It has received 19 citations till now. The article focuses on the topics: Cationic liposome & Liposome.read more
Citations
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Journal ArticleDOI
Factors affecting drug encapsulation and stability of lipid-polymer hybrid nanoparticles.
Wean Sin Cheow,Kunn Hadinoto +1 more
TL;DR: Antibiotics are encapsulated into hybrid nanoparticles intended for lung biofilm infection therapy and are examined in terms of their drug encapsulation efficiency, drug loading, stability, and in vitro drug release profile.
Journal ArticleDOI
Recent developments in protein and peptide parenteral delivery approaches
TL;DR: This review summarizes recent developments on some currently existing approaches to improve stability, bioavailability and bioactivity of peptide and protein therapeutics following parenteral administration.
Journal ArticleDOI
A rapid and simple HPLC method for the determination of curcumin in rat plasma: assay development, validation and application to a pharmacokinetic study of curcumin liposome.
TL;DR: The assay method was successfully applied to the study of the pharmacokinetics of curcumin liposome in rats and was sensitive with a lower limit of quantitation of 1 ng/mL, with good linearity over the linear range 1-500 ng/ mL.
Journal ArticleDOI
Comparison of liposome based antigen delivery systems for protection against Leishmania donovani.
TL;DR: Cationic MLV when used as adjuvant with protein antigens induced sustained Th1 immunity and mice challenged ten weeks after vaccination could also resist experimental challenge strongly.
Journal ArticleDOI
Formation strategies, mechanism of intracellular delivery and potential clinical applications of pH-sensitive liposomes
Xin Liu,Guihua Huang +1 more
TL;DR: P pH-sensitive liposomes can be successfully used in clinical if they enable the encapsulated drugs to be targeted to pathological tissues of the body in which pH is less than the normal physiological value.
References
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Journal ArticleDOI
Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation
TL;DR: A substantial fraction of the aqueous phase is entrapped within the vesicles, encapsulating even large macromolecular assemblies with high efficiency, and has unique advantages for encapsulating valuable water-soluble materials such as drugs, proteins, nucleic acids, and other biochemical reagents.
Journal ArticleDOI
A novel cationic liposome reagent for efficient transfection of mammalian cells
Xiang Gao,Leaf Huang +1 more
TL;DR: A novel cationic derivative of cholesterol, 3 beta [N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol), has been synthesized and used to prepare sonicated liposomes with dioleoylphosphatidylethanolamine and facilitates efficient DNA mediated transfection in A431 human epidermoid carcinoma cells.
Journal ArticleDOI
Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans
Gary J. Nabel,Elizabeth G. Nabel,Zhi-Yong Yang,Bernard A. Fox,Gregory E. Plautz,Xiang Gao,Leaf Huang,Suyu Shu,David Gordon,Alfred E. Chang +9 more
TL;DR: The feasibility, safety, and therapeutic potential of direct gene transfer in humans are demonstrated and regression of injected nodules on two independent treatments is demonstrated, accompanied by regression at distant sites.
Book ChapterDOI
Preparation and Use of Liposomes as Models of Biological Membranes
TL;DR: A considerable technical advance was made more than 10 years ago, when Mueller et al. as mentioned in this paper first reported a method for preparing usable preparations of bimolecular membrane from membrane molecules, the so-called black lipid membranes or BLMs.
BookDOI
Methods in membrane biology
TL;DR: Electron Microscopic Methods in Membrane Biology and the Use of Phospholipases in the Determination of Asymmetric Phosphoipid Distribution in membranes.