M
Mengxi Sun
Researcher at University of Chicago
Publications - 15
Citations - 658
Mengxi Sun is an academic researcher from University of Chicago. The author has contributed to research in topics: Pregnane X receptor & Fibrosis. The author has an hindex of 11, co-authored 15 publications receiving 418 citations. Previous affiliations of Mengxi Sun include University of California, San Diego & University of Kansas.
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Journal ArticleDOI
Reversibility of liver fibrosis.
Mengxi Sun,Tatiana Kisseleva +1 more
TL;DR: While most of the research has been focused on HSCs/myofibroblasts and inflammatory pathways, the crosstalk between different organs, various cell types and multiple signaling pathways should not be overlooked.
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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.
Hsiao-Yen Ma,Gen Yamamoto,Jun Xu,Xiao Liu,Daniel Karin,Ju Youn Kim,Ludmil B. Alexandrov,Yukinori Koyama,Takahiro Nishio,Christopher Benner,Sven Heinz,Sara Brin Rosenthal,Shuang Liang,Mengxi Sun,Gabriel Karin,Peng Zhao,Pnina Brodt,Iain H. McKillop,Oswald Quehenberger,Edward A. Dennis,Alan R. Saltiel,Hidekazu Tsukamoto,Bin Gao,Michael Karin,David A. Brenner,Tatiana Kisseleva +25 more
TL;DR: Overall, IL-17A is as a tumor promoting cytokine, which critically regulates alcohol-induced hepatic steatosis, inflammation, fibrosis, and HCC.
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Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver
TL;DR: This review focuses on the NR-mediated gene activation of drug and bile-acid transporters in these tissues as well as the possible underlying molecular mechanisms.
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Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis
Yukinori Koyama,Yukinori Koyama,Ping Wang,Ping Wang,Shuang Liang,Keiko Iwaisako,Xiao Liu,Jun Xu,Mingjun Zhang,Mengxi Sun,Min Cong,Min Cong,Daniel Karin,Kojiro Taura,Christopher Benner,Sven Heinz,Tapan K. Bera,David A. Brenner,Tatiana Kisseleva +18 more
TL;DR: It is demonstrated that activated PFs (aPFs) and myofibroblasts play a critical role in the pathogenesis of liver fibrosis induced by bile duct ligation (BDL), and in vitro analysis revealed that MSLN regulates TGF-&bgr;1–inducible activation of WT PFs by disrupting the formation of an inhibitory Thy-1–TGF&bGr;RI complex.
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Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
Duy Pham,Carson E. Moseley,Min Gao,Daniel Savic,Colleen J. Winstead,Mengxi Sun,Barbara L. Kee,Richard M. Myers,Casey T. Weaver,Robin D. Hatton +9 more
TL;DR: It is found that, in addition to its pioneering function, Batf controls developmentally regulated recruitment of the architectural factor Ctcf to promote chromatin looping that is associated with lineage-specific gene transcription.