Meral Yüksel

TL;DR: To detect changes in superoxide anion (O2−), nitric oxide (NO) and other reactive oxygen species (ROS) directly by measurement of chemilumin‐escence (CL) and to investigate the role of L‐arginine and NG‐nitro‐L ‐arg inine methyl ester in a rat mesenteric ischaemia‐reperfusion (I/R) model.

TL;DR: Investigation of the effect of ACE inhibition on trinitrobenzene sulphonic acid (TNBS)-induced colonic inflammation in rats by using captopril and lisinopril foundCaptopril treatment was found to be beneficial in all parameters, except colonic glutathione content, and although stimulation of lipid peroxidation and increase in serum TNF-alpha level were successfully prevented, the morphology of the lesions remained unchanged.

TL;DR: The data indicate that ET-1 causes PMN accumulation, oxidant stress, and mucosal dysfunction in the rat small intestine and thatET-1-induced mucosal Dysfunction involves a mechanism that includes a role for PMNs, ICAM-1, and PAF.

TL;DR: Findings suggest that pretreatment with the antioxidants superoxide dismutase or catalase has beneficial effects on the extent of colonic inflammation, particularly in the chronic period, and this may support the importance of antioxidant therapy to reduce the severity of inflammatory bowel disease in humans.

TL;DR: This study aimed to evaluate the potential beneficial effect of ALA on trinitrobenzenesulfonic acid (TNBS)‐induced gut ileitis and colitis in rats.