I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

http://europepmc.org/articles/PMC4146684?pdf=render

Cisplatin in cancer therapy: molecular mechanisms of action

羟氨苄青霉素引起大疱性类天疱疮样疹

ROS stress in cancer cells and therapeutic implications.

结节病易误诊,据王洪武等~([1])收集国内18篇关于此病误诊的文献,误诊率高达63.2%,当然有误诊就会有误治,如孙永昌等~([2])报道26例结节病在影像学检查诊断的第一印象中拟诊结核5例,其中就有2例完成规范的抗结核治疗,为此应引起临床对本病诊治的重视。

Sarcoidosis

Background: In diabetic nephropathy, increased excretion of glycosaminoglycans and loss of basement membrane anionic charge had been documented to be related with diabetic microalbumuniria. There was no study that studied those two factors in clinical settings with a degree of diabetic retinopathy in type 1 diabetics. Method: Forty subjects (aged 27.3 ± 6.3) with type 1 diabetes with different levels of diabetic retinopathy and 30 healthy subjects (aged 29.52 ± 8.7) were included in the study. Subjects were first divided as patients without (R0) and with (R1) retinopathy. They then were further divided into two subgroups with the help of fundus angiography as diabetic lesions demonstrable with fluorescein angiography (R1A) and early diabetic retinopathy lesions on fundus examination (R1B). Erythrocyte anionic charge (EAC) was determined by the binding of cationic dye, alcian blue, and urinary glycosaminoglycan excretion and (UGAG) was determined spectrophotometrically. Results: UGAG was increased (35.74 ±...

Erythrocyte membrane anionic content and urinary glycosaminoglycan excretion in type 1 diabetes : Association with retinopathy

The antifibrotic drug halofuginone reduces ischemia/reperfusion-induced oxidative renal damage in rats

Amac: Bu calismada melatonin ve amlodipinin iskemi/reperfuzyon (I/R) ile olusan beyin hasarina karsi olasi koruyucu etkileri arastirildi. Yontem: Wistar Albino sicanlar 15 dakika bilateral carotid arter okluzyonunu takiben 24 saat sureyle reperfuzyona birakildi. Melatonin ve amlodipin 10mg/kg ip veya 50µg/sican icv dozlarinda reperfuzyondan hemen once uygulandi. Norolojik tayin sonrasi hayvanlar dekapite edildi. Beyin dokularinda malondialdehit (MDA) ve glutatyon (GSH) duzeyleri ile myeloperoxidaz (MPO) ve Na+-K+-ATPaz aktiviteleri tayin edildi. Dokuda serbest radikal olusumu luminol ve lusigenin kemiluminesans (KL) yontemi ile olculdu. Beyin odemi yas/kuru agirlik uzerinden, kan beyin bariyer (KBB) gecirgenligi de Evans Mavisi (EM) extravazasyonu ile degerlendirilidi. Bulgular: Cozucu uygulanan grup ile karsilastirildiginda norolojik bozukluklarin melatonin ve amlodipin gruplarinda duzeldigi belirlendi. Iskemi/reperfuzyon beyinde GSH ve Na+-K+-ATPaz aktivitesinde azalma ve bununla birlikte MDA, MPO ve KL duzeylerinde artisa neden oldu. Buna karsilik melatonin ve amlodipin tedavileri tum incelenen biyokimyasal parametrelerdeki degisimi ve I/R nin neden oldugu beyin odemini geri cevirdi. Sonuc: Bu bulgulara gore gerek melatonin ve gerekse amlodipin muhtemelen antioksidan ozellikleri araciligi ile global iskemiye bagli olarak meydana gelen norokimyasal ve davranissal degisikleri module edebilecegi dusunulmektedir. Anahtar Kelimeler: melatonin, amlodipin, beyin, iskemi / reperfuzyon, lipid peroksidasyonu

/pdf/the-protective-effect-of-melatonin-and-amlodipine-against-32qhw09bf9.pdf

The protective effect of melatonin and amlodipine against cerebral ischemia/reperfusion-induced oxidative brain injury in rats

Objective: To assess the effect of pomegranate extract on acute inflammation due to myringotomy. Design: Prospective, randomised study. Subjects: Thirty Sprague-Dawley rats were divided into three groups. Group one constituted controls. Group two underwent myringotomy. Group three underwent myringotomy and also received 100 μl/day pomegranate extract, via gavage, one day before and two days after surgery. Following sacrifice 48 hours after myringotomy, the animals' right ears were used to determine the concentration of reactive oxygen species, using the chemiluminescence method; left ears were used for histological study. Results: Reactive oxygen species levels were significantly decreased in group three compared with group two (p < 0.01). The density of inflammatory cells in group three was significantly less than that in group two (p < 0.01). Lamina propria thickness and vessel density were also significantly decreased in group three compared with group two (p < 0.01). Conclusion: Our results indicate that oral pomegranate extract decreases reactive oxygen species concentration and acute inflammation in the tympanic membrane after myringotomy.

https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S002221511000263X

Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy.

The aim of this study is to evaluate the anti-inflammatory and anti-fibrotic effects of halofuginone in caustic esophageal burn injury in rats. Corrosive esophageal injury (CEI) was produced in male Wistar albino rats by instilling NaOH solution (1 ml, 37.5%) into the distal esophagus. Rats were decapitated on the 3rd day (early group) or 28th day (late group), and treated daily with either saline or halofuginone (100 µg/kg/day; i.p.), continued on alternate days after the third day. Histopathological evaluation and measurement of nitric oxide (NO), peroxynitrite (ONOO-) and oxygen-derived radicals by chemiluminescence (CL) were made in the distal 2 cm of the esophagus. Non-irrigated proximal esophageal samples were assessed for the levels of nuclear factor (NF)-κB, caspase-3, glutathione (GSH), malondialdehyde (MDA) and myeloperoxidase (MPO) activity. GSH, MDA, NF-κB and caspase-3 levels, and MPO activity in the proximal esophagus were not different among groups. Increased number of TUNEL (+) cells in the irrigated esophagus of the early and late caustic injury groups was reduced by halofuginone treatment. High microscopic damage scores in both early and late CEI groups were decreased with halofuginone treatment. NO, ONOO- and CL levels, which were elevated in the saline-treated early CEI group, were reduced by halofuginone treatment, but reduced NO and ONOO- levels in the late period of saline-treated group were increased by halofuginone. In addition to its anti-fibrotic effects, current findings demonstrate that halofuginone exerts antioxidant and anti-apoptotic actions and supports therapeutic potential for halofuginone in CEI-induced oxidative stress.

Meral Yüksel

Papers

Erythrocyte membrane anionic content and urinary glycosaminoglycan excretion in type 1 diabetes : Association with retinopathy

The antifibrotic drug halofuginone reduces ischemia/reperfusion-induced oxidative renal damage in rats

The protective effect of melatonin and amlodipine against cerebral ischemia/reperfusion-induced oxidative brain injury in rats

Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy.

Halofuginone improves caustic-induced oxidative injury of esophagus in rats