Mercè Brunet

TL;DR: ABTL0812 induces endoplasmic reticulum stress and blocks the Akt-mTOR axis; both actions converge to activate a robust and sustained autophagy leading to cancer cell death as mentioned in this paper.

TL;DR: High Treg levels in the peripheral blood of lung transplant recipients were associated with an increased risk of rejection but not infection, and low levels of activated CD8 T cells in infected patients were observed.

TL;DR: Current knowledge about PD biomarkers for personalized mTORi therapies seems promising, but before clinical implementation, the analytical methodologies must be standardized and cross-validated, and the selected biomarkers will have to demonstrate their clinical utility for SRL or EVR dose individualization in multicenter clinical trials.

TL;DR: In this article, the authors used miRNAs to diagnose T cell-mediated rejection after liver transplantation (LT) and compared their accuracy with previously published tests for diagnosing TCMR based on routine laboratory parameters.

TL;DR: Atorvastatin proved to be an immunomodulatory agent, significantly decreasing lymphocyte proliferation, increasing ATP levels, and showing a trend toward increasing Treg cells in hypercholesterolemic patients, suggesting that the beneficial effects of atorVastatin in this patient group do not relate to immunoregulation.