Showing papers in "Liver Transplantation in 2020"
TL;DR: The Lombardy region of Italy has become one of the areas of highest incidence of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) and the concern that immunocompromised patients may be at high risk of developing a severe respiratory disease called COVID-19 is raised.
566 citations
Baylor University Medical Center1, University of Minnesota2, Stanford University3, Johns Hopkins University4, University of Pittsburgh5, Baylor University6, Mount Sinai Hospital7, University of Miami8, University of Michigan9, University of Wisconsin-Madison10, Mayo Clinic11, University of Southern California12
TL;DR: Recommendations for programs that perform or plan to perform liver transplantation for alcohol associated hepatitis (AH) were proposed and criteria were established to determine candidacy for LT in the setting of AH.
72 citations
TL;DR: RRLDH is feasible, safe, and reproducible, with significantly decreased blood loss and a shorter hospital stay compared with the open procedure, and the first 35 patients receiving the robotic procedure showed a substantial reduction in operative time, reflecting a rapid shortening of the learning curve.
49 citations
TL;DR: Overall, aggressive management of metabolic syndrome after LT via medical and surgical modalities and a minimalist approach to immunosuppression is advised.
48 citations
TL;DR: LT may offer a benefit for highly selected patients with cirrhosis and unresectable iCCA/cHCC‐CCA having tumors ≤5 cm and efforts should be made to evaluate tumor differentiation, and these results need to be confirmed prospectively in a larger population.
48 citations
TL;DR: Because IRI and EAD are closely linked, more attention should be paid to the underlying mechanisms and the fundamental relationship between them, which may play a crucial role in the prevention of EAD.
48 citations
Cedars-Sinai Medical Center1, Hospital of the University of Pennsylvania2, University of Pennsylvania3, Royal Free Hospital4, Stanford University5, University of Alberta6, Cornell University7, Baylor University Medical Center8, Northwestern University9, Oregon Health & Science University10, University of Colorado Denver11, University of Western Ontario12
TL;DR: Patients transplanted with ACLF grade 3 had lower 5‐year survival as compared with patients with ACLf grades 0‐2, but mortality rates were not significantly different after the first year following LT, and graft survival was excellent across all ACLF groups.
45 citations
TL;DR: The COVID‐19 pandemic, caused by the SARS‐CoV‐2 virus, has been devastating to health care delivery in many parts of the US and has had a significant impact on organ transplantation.
42 citations
TL;DR: The evidence supporting LT in ACLF patients is outlined, highlighting the role of timing, bridging to LT, and possible indicators of futility, and prospective studies on ACLF and transplantation are urgently needed.
42 citations
TL;DR: Posttransplant exercise improves fitness, which is a conclusion based on 2 observational studies and 3 randomized trials that assessed endpoints of strength testing, energy expenditure in metabolic equivalents, and peak or maximal oxygen uptake.
39 citations
TL;DR: The OrganOx metra using a back‐to‐base approach has enabled the safe use of 10 high‐risk orphan donor livers with 100% 6‐month patient and graft survival and has enabled a safe expansion of the donor pool.
TL;DR: Pre‐LT CKD has a deleterious impact on post‐LT outcomes, which is an impact that is not mediated through SLKT, and the findings highlight the need for the identification of CKD when preventative measures are possible.
TL;DR: A systematic review of studies predicting graft outcomes following deceased donor liver transplantation using AI techniques and to compare these findings to linear regression and standard predictive modeling found AI techniques can provide high accuracy in predicting graft survival based on donors and recipient variables.
University of Pisa1, Sapienza University of Rome2, University of Milan3, University of Turin4, University of Padua5, University of Florence6, University of Pittsburgh7, University of Bologna8, University of Rome Tor Vergata9, University of Palermo10, University of Zurich11, University of Cambridge12, University Hospitals Birmingham NHS Foundation Trust13, Cleveland Clinic14, Toronto General Hospital15
TL;DR: A critical and scientific approach is required for the safe implementation of this new technology in liver transplantation and according to the Grading of Recommendations Assessment, Development, and Evaluation method.
Agostino Gemelli University Polyclinic1, University of Udine2, University of Padua3, University of Pisa4, ISMETT5, University of Modena and Reggio Emilia6, University of Milan7, University of Turin8, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico9, Sapienza University of Rome10, University of Rome Tor Vergata11
TL;DR: Overall, SARS‐CoV‐2 infection was registered for 24 liver transplant recipients and 37 health care providers in liver transplant units, and more data will be required to define appropriate strategies for the increasingly complex management of liver transplant patients.
TL;DR: Systematic use of NRP limits liver damage induced by warm ischemia and provides excellent cDCD organs for transplant and results were observed where the national protocol was followed.
TL;DR: It is shown that ex situ NMP of human livers can be performed safely and effectively using a noncommercial device and an FFP‐based preservation solution.
TL;DR: It was shown that patients with ESLD are able to use and interact with the EL‐FIT app, a novel smartphone app that has the potential of becoming an invaluable tool for home‐based prehabilitation in LT candidates.
TL;DR: This research presents a novel and scalable approach to personalized medicine that aims to provide real-time information about the immune system’s response to infectious disease.
TL;DR: Over half of adolescent LT recipients appear to be at risk for poor school and cognitive functioning, likely reflecting attention and executive function deficits, and these deficits seem to persist in adolescence.
TL;DR: The SIPAT score was independently associated with LT listing decisions and IS nonadherence, and the readiness domain was associated with the risk of allograft rejection, offering insights into higher risk recipients who require additional support before and after transplantation.
TL;DR: In patients with HCC <3 cm in diameter,LR‐TR criteria after TA had high IRR but low sensitivity, suggesting that the LR‐TR categories are precise but inaccurate, and new technologies may be necessary to improve imaging after ablation.
TL;DR: This review discusses current literature on biliary biomarkers that could predict or assess liver graft and bile duct viability and offers an exciting and novel perspective in the search for reliable hepatocyte and cholangiocyte viability biomarkers.
TL;DR: RAC is associated with a high risk of liver decompensation and a poor prognosis and prevention of severe alcohol relapse after LT is a major goal to improve patient survival.
North Shore University Hospital1, Hofstra University2, University of Memphis3, Methodist University4, Kansas State University5, University of Nottingham6, University of Miami7, Post Graduate Institute of Medical Education and Research8, Baylor College of Medicine9, University of Toronto10, Virginia Commonwealth University11, The Chinese University of Hong Kong12, Duke University13, Stanford University14, University of Maryland, Baltimore15, University of South Dakota16
TL;DR: Adult recipients selected for first LT and NASH patients with the lowest BMI have the worse longterm graft and patient survival as opposed to non‐NASH patients where the survival was worse with higher BMI.
TL;DR: It is suggested that TEE is an effective form of monitoring with a safety profile similar to that in cardiac surgery patients and should be adopted by transplant anesthesiologists.
TL;DR: Minimally invasive alternative tools, such as liquid biopsy, are being increasingly explored and could help to individualize risk stratification for patients with HCC who will benefit from LT despite being outside the accepted clinical criteria.
University of Hamburg1, University of Paris-Sud2, University of Valencia3, Queen Elizabeth Hospital Birmingham4, Shiraz University of Medical Sciences5, University of Cambridge6, Leeds Teaching Hospitals NHS Trust7, Charité8, University of Rennes9, University of Duisburg-Essen10, Medical University of Warsaw11, University Hospital Heidelberg12
TL;DR: Autoimmune hepatitis (AIH) patients with living donor liver transplantation (LDLT) showed reduced survival compared with patients receiving donation after brain death (HR, 1.96; P < 0.001) and in AIH‐LT patients, overall survival is inferior to PBC‐LT and PSC‐LT.
TL;DR: Using a national cohort, the NACSELD‐ACLF score was externally validated as an excellent, simple bedside tool to predict short‐term survival in patients with decompensated cirrhosis and compared outcomes depending on presence of infection or hospitalization at a transplant center.
TL;DR: The novel Severe Acute Respiratory Syndrome Coronavirus (COVID‐19) disease represents an unprecedented public health issue for the general population and for patients with underlying chronic conditions.