Merja Matilainen

TL;DR: In this paper, the power of transcriptional profiling to uncover novel PPARα-regulated genes and pathways in liver was illustrated, using an in silico screening approach, one or more PPAR response elements were identified in each of these genes.

TL;DR: In this paper, the authors performed expression profiling of all six human insulin-like growth factor binding proteins (IGFBPs) in prostate and bone cancer cells and demonstrated that IGFBP1, 3 and 5 are primary 1α,25-dihydroxyvitamin D3 target genes.

TL;DR: The ligand-independent tight control of the position of the PPAR helix 12 provides an effective alternative for establishing an interaction with CoA proteins and leads to high basal activity of PPARs and provides an additional view on PPAR signaling.

TL;DR: This study created a position weight matrix (PWM) for PXR-RXR heterodimers that took the relative in vitro binding strength and not only the sequence of natural and synthetic PxR binding sites (PXREs) into account, and extended the discriminatory power of the matrix by including the variation of the dinucleotides 5'-flanking the hexameric binding motifs.

TL;DR: It is demonstrated, in human hepatocellular carcinoma cells and in normal mouse liver, that IGFBP-1 mRNA expression is under the primary control of PPAR ligands.