Merja Perälä

TL;DR: The COL9A2 gene, which codes for one of the polypeptide chains of collagen IX that is expressed in the intervertebral disc, was screened for sequence variations in individuals with interverTEbral disc disease and identified a putative disease-causing sequence variation that converted a codon for glutamine to one for tryptophan.

TL;DR: This study presents and analyzes data derived from expression profiling of 799 miRNAs in 101 primary human breast tumors, along with genome-wide mRNA profiles and extensive clinical information, to identify statistical significant differential expression of mi RNAs between molecular intrinsic subtypes, and between samples with different levels of proliferation.

TL;DR: This study led to the identification of a novel common genetic risk factor for LDD, confirming that genetic risk factors likely play a significant role in LDD.

TL;DR: It is established that miRNAs interacting with the long 3'UTR of the AR gene are important regulators of AR protein levels, with implications for developing new therapeutic strategies to inhibit AR function and androgen-dependent cell growth.

TL;DR: In this article, the authors applied a protein lysate microarray (LMA) technology to systematically monitor for target protein levels after high-throughput transfections of 319 pre-miRs into breast cancer cells.