Metka Novak

TL;DR: Focusing on one stromal component in the glioblastoma niches, the mesenchymal stem cells (MSCs), the major hindrance to metastatic progression of mCSCs seem to be crossing the blood-brain-barrier in brain metastases.

TL;DR: CCL5/CCR5 is suggested to be an excellent new target for glioblastoma therapy and the molecular mechanisms, by which chemoattractant and receptor respond within the complex tissue microenvironment to promote cancer stem cells and tumour heterogeneity, should be considered in forthcoming studies.

TL;DR: In this paper, the authors summarize the glioblastoma characteristics that drive tolerance to immunotherapy, the currently used immunotherapeutic approaches, and the most suitable tumor models to mimic conditions in brain malignant tumor patients.

TL;DR: Autocrine and paracrine cross-talk in glioblastoma and, in particular, gli oblastoma stem cells with its stromal microenvironment, involves CCR5 and CCL5, contributing to gliOBlastoma invasion, suggesting the CCL 5/CCR5 axis as a potential therapeutic target that can be targeted with repositioned drug maraviroc.

TL;DR: In this article, the cytotoxic, apoptotic, and anti-invasive effects of the purified natural cannabinoid CBG together with CBD and THC on established differentiated glioblastoma tumour cells and stem cells were compared.