M
Metodi V. Metodiev
Researcher at University of Essex
Publications - 56
Citations - 1697
Metodi V. Metodiev is an academic researcher from University of Essex. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 21, co-authored 56 publications receiving 1434 citations. Previous affiliations of Metodi V. Metodiev include Bulgarian Academy of Sciences & University of Illinois at Chicago.
Papers
More filters
Journal ArticleDOI
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer
Alison Harrod,J Fulton,Van T. M. Nguyen,Manikandan Periyasamy,L Ramos-Garcia,C-F Lai,Gergana Metodieva,A de Giorgio,R L Williams,D B Santos,P J Gomez,M-L Lin,Metodi V. Metodiev,Justin Stebbing,Leandro Castellano,Luca Magnani,R. C. Coombes,Laki Buluwela,Simak Ali +18 more
TL;DR: The functional importance of ER mutations in endocrine resistance, the utility of knock-in mutational models for investigating alternative therapeutic approaches and CDK7 inhibition as a potential therapy for endocrine-resistant breast cancer mediated by ER mutations are confirmed.
Journal ArticleDOI
Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p
TL;DR: A model wherein activated Fus3p is recruited back to the cortex, where it activates Bni1p to promote polarization and cell fusion is suggested.
Journal ArticleDOI
Regulation of MAPK function by direct interaction with the mating-specific Gα in yeast
TL;DR: This work has found that Gα binds directly to the mating-specific MAPK in yeast cells responding to pheromone, and it demonstrates direct communication between the top and bottom of a Gα-MAPK pathway.
Journal ArticleDOI
Stat1 and CD74 overexpression is co-dependent and linked to increased invasion and lymph node metastasis in triple-negative breast cancer.
Christina Greenwood,Gergana Metodieva,Khalid Al-Janabi,Berthold Lausen,Louise Caroline Alldridge,Lin Leng,Richard Bucala,Nelson Fernandez,Metodi V. Metodiev +8 more
TL;DR: The results show that Stat1/CD74 positive triple-negative tumors are more aggressive and suggest an approach for development of better diagnostics and more targeted therapies for triple negative breast cancer.
Journal ArticleDOI
Thioredoxin-mediated reversible dissociation of a stromal multiprotein complex in response to changes in light availability
TL;DR: It is shown here that both PRK and GAPDH are present in the reduced form in leaves in the dark, but are inactive, demonstrating the role of the PRK/GAPDH/CP12 complex in deactivating these enzymes in response to reductions in light intensity.