M
Manikandan Periyasamy
Researcher at Imperial College London
Publications - 25
Citations - 1356
Manikandan Periyasamy is an academic researcher from Imperial College London. The author has contributed to research in topics: Estrogen receptor & Breast cancer. The author has an hindex of 17, co-authored 24 publications receiving 1087 citations. Previous affiliations of Manikandan Periyasamy include Emory University.
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Journal ArticleDOI
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
Simak Ali,Dean A. Heathcote,Sebastian H. B. Kroll,Ashutosh S. Jogalekar,Bodo Scheiper,Hetal Patel,Jan Brackow,Alekasandra Siwicka,Matthew J. Fuchter,Manikandan Periyasamy,Robert S. Tolhurst,Seshu K. Kanneganti,James P. Snyder,Dennis C. Liotta,Eric O. Aboagye,Anthony G. M. Barrett,R. Charles Coombes +16 more
TL;DR: BS-181, a pyrazolo[1,5-a]pyrimidine-derived compound, provides the first example of a potent and selective CDK7 inhibitor with potential as an anticancer agent.
Journal ArticleDOI
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer
Alison Harrod,J Fulton,Van T. M. Nguyen,Manikandan Periyasamy,L Ramos-Garcia,C-F Lai,Gergana Metodieva,A de Giorgio,R L Williams,D B Santos,P J Gomez,M-L Lin,Metodi V. Metodiev,Justin Stebbing,Leandro Castellano,Luca Magnani,R. C. Coombes,Laki Buluwela,Simak Ali +18 more
TL;DR: The functional importance of ER mutations in endocrine resistance, the utility of knock-in mutational models for investigating alternative therapeutic approaches and CDK7 inhibition as a potential therapy for endocrine-resistant breast cancer mediated by ER mutations are confirmed.
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miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts
Loredana Pellegrino,Justin Stebbing,Vania M.M. Braga,Adam E Frampton,Jimmy Jacob,Lakjaya Buluwela,Long R. Jiao,Manikandan Periyasamy,Chris D. Madsen,M. Caley,Silvia Ottaviani,Laura Roca-Alonso,Mona El-Bahrawy,R. Charles Coombes,Jonathan Krell,Leandro Castellano +15 more
TL;DR: It is shown that miR-23b regulates focal adhesion, cell spreading, cell-cell junctions and the formation of lamellipodia in breast cancer (BC), implicating a central role for it in cytoskeletal dynamics.
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Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion
Van T. M. Nguyen,Iros Barozzi,Monica Faronato,Ylenia Lombardo,Jennifer H. Steel,Naina Patel,Philippa D. Darbre,Leandro Castellano,Balázs Győrffy,Laura Woodley,Alba Rodriguez Meira,Darren K. Patten,Valentina Vircillo,Manikandan Periyasamy,Simak Ali,Gianmaria Frigè,Saverio Minucci,R. Charles Coombes,Luca Magnani +18 more
TL;DR: It is demonstrated that resistance emerges via drug-specific epigenetic reprogramming in AI-resistant cells and Epigenomic-led stratification can predict resistance to AI in a subset of ERα-positive patients.
Journal ArticleDOI
The DEAD-box protein p72 regulates ERα-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERα-positive breast cancer
Noel C. Wortham,E Ahamed,Samantha M. Nicol,Ross S. Thomas,Manikandan Periyasamy,Jie Jiang,Anna Maria Ochocka,Sami Shousha,Les Huson,Susan E. Bray,R. C. Coombes,Simak Ali,Frances V. Fuller-Pace +12 more
TL;DR: A crucial role for p72 is highlighted in ERα co-activation and oestrogen-dependent cell growth and evidence in support of distinct but important roles for both p68 and p72 in regulating ERα activity in breast cancer is provided.