S
Simak Ali
Researcher at Imperial College London
Publications - 152
Citations - 11102
Simak Ali is an academic researcher from Imperial College London. The author has contributed to research in topics: Breast cancer & Estrogen receptor. The author has an hindex of 53, co-authored 138 publications receiving 9964 citations. Previous affiliations of Simak Ali include Collège de France & Hammersmith Hospital.
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Journal ArticleDOI
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
Robert Campbell,Poornima Bhat-Nakshatri,Nikhil M. Patel,Demetra Constantinidou,Simak Ali,Harikrishna Nakshatri +5 more
TL;DR: A molecular link between activation of the PI 3-kinase/AKT survival pathways, hormone-independent activation of ERα, and inhibition of tamoxifen-induced apoptotic regression is defined.
Journal ArticleDOI
Endocrine-responsive breast cancer and strategies for combating resistance.
Simak Ali,R. Charles Coombes +1 more
TL;DR: The mechanisms that underlie many breast tumours either fail to respond or become resistant to endocrine therapies are understood to develop strategies for overcoming or bypassing it.
Journal Article
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.
TL;DR: The present studies confirm the potent dose-dependent antitumor activity of TSA against breast cancer in vitro and in vivo, strongly supporting HDAC as a molecular target for anticancer therapy in breast cancer.
Journal ArticleDOI
Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region.
TL;DR: The authors showed that the human oestrogen receptor (hER) becomes phosphorylated in the presence of oestradiol (E2) and anti-oestrogens 4-hydroxy-tamoxifen (OHT) and ICI 164, 384 (ICI), although at lower efficiencies than with E2.
Journal ArticleDOI
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.
Suzanne A. Eccles,Eric O. Aboagye,Simak Ali,Annie S. Anderson,Jo Armes,Fedor Berditchevski,Jeremy P. Blaydes,Keith Brennan,Nicola J. Brown,Helen E. Bryant,Nigel J Bundred,Joy Burchell,Anna Campbell,Jason S. Carroll,Robert Clarke,Charlotte E. Coles,Gary Cook,Angela Cox,Nicola J. Curtin,Lodewijk V. Dekker,Isabel dos Santos Silva,Stephen W. Duffy,Douglas F. Easton,Diana Eccles,Dylan R. Edwards,Joanne Edwards,D. G. R. Evans,Deborah Fenlon,James M. Flanagan,Claire Foster,William M. Gallagher,Montserrat Garcia-Closas,Julia Margaret Wendy Gee,Andy J. Gescher,Vicky Goh,Ashley M. Groves,Amanda J. Harvey,Michelle Harvie,Bryan T. Hennessy,Stephen Edward Hiscox,Ingunn Holen,Sacha J Howell,Anthony Howell,Gill Hubbard,Nicholas J. Hulbert-Williams,Myra S. Hunter,Bharat Jasani,Louise J. Jones,Timothy J. Key,Cliona C. Kirwan,Anthony Kong,Ian Kunkler,Simon P. Langdon,Martin O. Leach,David J. Mann,John Marshall,Lesley Ann Martin,Stewart G. Martin,Jennifer E. Macdougall,David Miles,William R. Miller,Joanna R. Morris,Sue Moss,Paul B. Mullan,Rachel Natrajan,James P B O'Connor,Rosemary O'Connor,Carlo Palmieri,Paul D.P. Pharoah,Emad A. Rakha,Elizabeth Reed,Simon P. Robinson,Erik Sahai,John M. Saxton,Peter Schmid,Matthew J. Smalley,Valerie Speirs,Robert Stein,John Stingl,Charles H. Streuli,Andrew Tutt,Galina Velikova,Rosemary A. Walker,Christine J. Watson,Kaye J. Williams,Leonie S. Young,Alastair M. Thompson +86 more
TL;DR: With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.