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Stefan Vinckier
Researcher at Katholieke Universiteit Leuven
Publications - 69
Citations - 5786
Stefan Vinckier is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Angiogenesis & Medicine. The author has an hindex of 33, co-authored 62 publications receiving 4180 citations. Previous affiliations of Stefan Vinckier include Flanders Institute for Biotechnology.
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Journal ArticleDOI
HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.
Charlotte Rolny,Massimiliano Mazzone,Sonia Tugues,Damya Laoui,Irja Johansson,Cathy Coulon,Mario Leonardo Squadrito,Inmaculada Segura,Xiujuan Li,Ellen Knevels,Sandra Costa,Stefan Vinckier,Tom Dresselaer,Peter Åkerud,Maria De Mol,Henriikka Salomäki,Mia Phillipson,Sabine Wyns,Erik G. Larsson,Ian Buysschaert,Johan Botling,Uwe Himmelreich,Jo A. Van Ginderachter,Michele De Palma,Mieke Dewerchin,Lena Claesson-Welsh,Peter Carmeliet +26 more
TL;DR: It is reported that the host-produced histidine-rich glycoprotein (HRG) inhibits tumor growth and metastasis, while improving chemotherapy, and offers therapeutic opportunities for anticancer and antiangiogenic treatment.
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Single-Cell Transcriptome Atlas of Murine Endothelial Cells
Joanna Kalucka,Laura P.M.H. de Rooij,Jermaine Goveia,Katerina Rohlenova,Sébastien J. Dumas,Elda Meta,Nadine V. Conchinha,Federico Taverna,Laure-Anne Teuwen,Koen Veys,Melissa García-Caballero,Shawez Khan,Vincent Geldhof,Liliana Sokol,Rongyuan Chen,Lucas Treps,Mila Borri,Pauline de Zeeuw,Charlotte Dubois,Tobias K. Karakach,Kim D. Falkenberg,Magdalena Parys,Xiangke Yin,Stefan Vinckier,Yuxiang Du,Robert A. Fenton,Luc Schoonjans,Luc Schoonjans,Mieke Dewerchin,Guy Eelen,Bernard Thienpont,Lin Lin,Lars Bolund,Xuri Li,Yonglun Luo,Peter Carmeliet,Peter Carmeliet +36 more
TL;DR: An atlas of >32,000 single-EC transcriptomes from 11 mouse tissues was constructed and 78 EC subclusters were identified, including Aqp7+ intestinal capillaries and angiogenic ECs in healthy tissues and provides a powerful discovery tool and resource value.
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Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Sandra Schoors,Ulrike Bruning,Rindert Missiaen,Karla C. S. Queiroz,Gitte Borgers,Ilaria Elia,Annalisa Zecchin,Anna Rita Cantelmo,Stefan Christen,Jermaine Goveia,Ward Heggermont,Lucica Godde,Stefan Vinckier,Paul P. Van Veldhoven,Guy Eelen,Luc Schoonjans,Holger Gerhardt,Mieke Dewerchin,Myriam Baes,Katrien De Bock,Bart Ghesquière,Sophia Y. Lunt,Sarah-Maria Fendt,Peter Carmeliet +23 more
TL;DR: It is reported that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells.
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Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.
Sandra Schoors,Katrien De Bock,Anna Rita Cantelmo,Maria Georgiadou,Bart Ghesquière,Sandra Cauwenberghs,Anna Kuchnio,Brian W. Wong,Annelies Quaegebeur,Jermaine Goveia,Francesco Bifari,Xingwu Wang,Raquel Blanco,Bieke Tembuyser,Ivo Cornelissen,Ann Bouché,Stefan Vinckier,Santiago Diaz-Moralli,Holger Gerhardt,Holger Gerhardt,Sucheta Telang,Marta Cascante,Jason Chesney,Mieke Dewerchin,Peter Carmeliet +24 more
TL;DR: Although 3PO reduced glycolysis only partially and transiently in vivo, this sufficed to decrease pathological neovascularization in ocular and inflammatory models and may offer therapeutic antiangiogenic opportunities.
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Tumor Vessel Normalization by Chloroquine Independent of Autophagy
Hannelore Maes,Anna Kuchnio,Aleksandar Peric,Stijn Moens,Kris Nys,Katrien De Bock,Annelies Quaegebeur,Sandra Schoors,Maria Georgiadou,Jasper Wouters,Stefan Vinckier,Hugo Vankelecom,Marjan Garmyn,Anne-Clémence Vion,Freddy Radtke,Chantal M. Boulanger,Holger Gerhardt,Holger Gerhardt,Elisabetta Dejana,Mieke Dewerchin,Bart Ghesquière,Wim Annaert,Patrizia Agostinis,Peter Carmeliet +23 more
TL;DR: By normalizing tumor vessel structure and function and increasing perfusion, CQ reduced hypoxia, cancer cell invasion, and metastasis, while improving chemotherapy delivery and response, supporting the use of CQ for anticancer treatment.