M
Michael A. Kienzler
Researcher at University of California, Berkeley
Publications - 23
Citations - 1069
Michael A. Kienzler is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Photoswitch & Chemistry. The author has an hindex of 12, co-authored 20 publications receiving 844 citations. Previous affiliations of Michael A. Kienzler include Helen Wills Neuroscience Institute & Marine Biological Laboratory.
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Journal ArticleDOI
A red-shifted, fast-relaxing azobenzene photoswitch for visible light control of an ionotropic glutamate receptor.
TL;DR: The synthesis and characterization of a red-shifted PTL, L-MAG0460, for the light-gated ionotropic glutamate receptor LiGluR, and visible light excitation and single-wavelength behavior considerably simplify use and should improve utilization in tissue.
Journal ArticleDOI
Tuning Photochromic Ion Channel Blockers
Alexandre Mourot,Michael A. Kienzler,Matthew R. Banghart,Timm Fehrentz,Florian M. E. Huber,Marco Stein,Richard H. Kramer,Dirk Trauner +7 more
TL;DR: Red-shifted compounds that fully operate in the visible region of the spectrum and quickly turn themselves off in the dark are introduced, and a version that does not block effectively in thedark-adapted state, can be switched to a blocking state with blue light, and reverts to the inactive state automatically is developed.
Journal ArticleDOI
HTR7 mediates serotonergic acute and chronic itch
Takeshi Morita,Takeshi Morita,Shannan P. McClain,Lyn Batia,Maurizio Pellegrino,Sarah R. Wilson,Sarah R. Wilson,Michael A. Kienzler,Kyle A. Lyman,Anne Sofie Braun Olsen,Justin F. Wong,Cheryl L. Stucky,Rachel B. Brem,Rachel B. Brem,Diana M. Bautista,Diana M. Bautista +15 more
TL;DR: A role for HTR7 in acute and chronic itch is highlighted and it is suggested that H TR7 antagonists may be useful for treating a variety of pathological itch conditions.
Journal ArticleDOI
Restoring Vision to the Blind with Chemical Photoswitches
Ivan Tochitsky,Ivan Tochitsky,Michael A. Kienzler,Ehud Y. Isacoff,Ehud Y. Isacoff,Ehud Y. Isacoff,Richard H. Kramer,Richard H. Kramer +7 more
TL;DR: The development and translational application of light-sensitive chemical photoswitched to restore visual function to the blind retina is described and the translational potential of photoswitches with other vision-restoring therapies are compared.
Journal ArticleDOI
Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells
Benjamin M. Gaub,Michael H. Berry,Amy Holt,Andreas Reiner,Michael A. Kienzler,Natalia Dolgova,Sergei Nikonov,Gustavo D. Aguirre,William A. Beltran,John G. Flannery,John G. Flannery,Ehud Y. Isacoff,Ehud Y. Isacoff +12 more
TL;DR: Retinal function in visible light in rodent and canine models of blindness is restored through the use of a second-generation photoswitch for LiGluR, maleimide-azobenzene-glutamate 0 with peak efficiency at 460 nm (MAG0460).