M
Michael Di Palma
Researcher at University of Urbino
Publications - 29
Citations - 585
Michael Di Palma is an academic researcher from University of Urbino. The author has contributed to research in topics: Heteroreceptor & Medicine. The author has an hindex of 12, co-authored 25 publications receiving 428 citations. Previous affiliations of Michael Di Palma include Marche Polytechnic University & Karolinska Institutet.
Papers
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Journal ArticleDOI
The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components
Dasiel O. Borroto-Escuela,Ismel Brito,Wilber Romero-Fernandez,Michael Di Palma,Julia Oflijan,Kamila Skieterska,Jolien Duchou,Kathleen Van Craenenbroeck,Diana Suárez-Boomgaard,Alicia Rivera,Diego Guidolin,Luigi F. Agnati,Kjell Fuxe +12 more
TL;DR: A collective interaction network was constructed to provide insight into the overall topology of the GPCR heteromers and identify key players and a significant dominance of intrafamily versus interfamily connections is revealed.
Journal ArticleDOI
Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E.
Patrizia Ambrogini,Pierangelo Torquato,Desirée Bartolini,Maria Cristina Albertini,Davide Lattanzi,Michael Di Palma,Rita Marinelli,Michele Betti,Andrea Minelli,Riccardo Cuppini,Francesco Galli +10 more
TL;DR: An overview of the literature supporting the potential for a timely intervention with vitamin E therapy in clinical management of seizures and epileptogenic processes associated with excitotoxicity, neuroinflammation and lipid peroxidation, i.e. the pathogenic "triad" is provided.
Book ChapterDOI
In Situ Proximity Ligation Assay to Study and Understand the Distribution and Balance of GPCR Homo- and Heteroreceptor Complexes in the Brain
Dasiel O. Borroto-Escuela,Beth Hagman,Miles Woolfenden,Luca Pinton,Antonio Jiménez-Beristain,Julia Oflijan,Manuel Narváez,Michael Di Palma,Kristin Feltmann,Stfano Sartini,Patrizia Ambrogini,Francisco Ciruela,Riccardo Cuppini,Kjell Fuxe +13 more
Journal ArticleDOI
Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder
Dasiel O. Borroto-Escuela,Dasiel O. Borroto-Escuela,Manuel Narváez,Karolina Wydra,Julia Pintsuk,Julia Pintsuk,Luca Pinton,Antonio Jiménez-Beristain,Michael Di Palma,Joanna Jastrzębska,Małgorzata Filip,Kjell Fuxe +11 more
TL;DR: It is suggested that cocaine self‐administration can reorganize A2AR and D2R into increased A2 AR‐D2R heteroreceptor complexes in the nucleus accumbens shell associated with increases in the D 2R‐sigma1R heteroresceptic complexes in this region.
Journal ArticleDOI
Preferential activation by galanin 1-15 fragment of the GalR1 protomer of a GalR1-GalR2 heteroreceptor complex.
Dasiel O. Borroto-Escuela,Manuel Narváez,Michael Di Palma,Feliciano Calvo,David Rodríguez,Carmelo Millón,Jens Carlsson,Luigi F. Agnati,Pere Garriga,Zaida Díaz-Cabiale,Kjell Fuxe +10 more
TL;DR: Results suggested that the orthosteric agonist binding site of GalR1 protomer may have an increased affinity for the galanin (1-15) vs galAnin ( 1-29) which can lead to its demonstrated increase in potency to inhibit CREB vs galan in (1 -29).