M
Michael Feldgarden
Researcher at National Institutes of Health
Publications - 35
Citations - 21095
Michael Feldgarden is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome & Human microbiome. The author has an hindex of 24, co-authored 32 publications receiving 18253 citations. Previous affiliations of Michael Feldgarden include Broad Institute & Harvard University.
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Journal ArticleDOI
Erratum for Feldgarden et al., "Validating the AMRFinder Tool and Resistance Gene Database by Using Antimicrobial Resistance Genotype-Phenotype Correlations in a Collection of Isolates".
Michael Feldgarden,Vyacheslav Brover,Daniel H. Haft,Arjun B. Prasad,Douglas J. Slotta,Igor Tolstoy,Gregory H. Tyson,Shaohua Zhao,Chih-Hao Hsu,Patrick F. McDermott,Daniel A. Tadesse,Cesar A. Morales,Mustafa Simmons,Glenn E. Tillman,Jamie L. Wasilenko,Jason P. Folster,William Klimke +16 more
TL;DR: This poster presents a probabilistic procedure to characterize Enteric Diseases Laboratory Branch at the National Institutes of Health (NIH) in Bethesda, Maryland as to how enteric diseases in animals and humans are influenced by each other.
Molecular complexity of successive bacterial epidemics deconvoluted by comparative
B. Beres,Ronan K. Carroll,Patrick R. Shea,Izabela Sitkiewicz,Juan Carlos Martinez-Gutierrez,Michael Feldgarden,Bruce W. Birren,Yuriy Fofanov,John Boos,William D. Wheaton,Christiane Honisch,James M. Musser +11 more
TL;DR: It is concluded that enhanced understanding of bacterial epidemics requires a deep-sequencing, geographically centric, comparative pathogenomics strategy.
Journal ArticleDOI
Evaluation of bacterial ribosomal RNA (rRNA) depletion methods for sequencing microbial community transcriptomes
Dawn Ciulla,Georgia Giannoukos,Ashlee M. Earl,Michael Feldgarden,Dirk Gevers,Joshua Z. Levin,Jonathan Livny,Doyle V. Ward,Andreas Gnirke,Chad Nusbaum,Bruce W. Birren +10 more
TL;DR: Determining enrichment efficiency by sequencing is very costly, thus the authors are developing qPCR assays for high, mid, and low expressed genes and the 16S and 23S rRNA genes for these organisms, and they will assess changes in rRNA/mRNA ratios with different depletion rRNA methods.
Journal ArticleDOI
Curation of the AMRFinderPlus databases: applications, functionality and impact
Michael Feldgarden,Vyacheslav Brover,Boris Fedorov,Daniel H. Haft,Arjun B. Prasad,William Klimke +5 more
TL;DR: This work describes how to curate the genes, point mutations and blast rules, and hidden Markov models used in NCBI’s AMRFinderPlus, along with the quality-control steps taken to ensure database quality, and discusses how the computed analyses generated by those tools can be accessed through a web interface.
Journal ArticleDOI
Lessons learned in virulence factor identification and data management from a hackathon on microbial virulence
Brett E. Pickett,Ryan Connor,Tamiru Berhanu-Denka,Sherry Bhalla,Vyacheslav Brover,Michael Chambers,Kumardeep Chaudhary,Ousmane H. Cissé,Allissa Dillman,Moamen M. Elmassry,Michael Feldgarden,E. Holloway,Xin Huang,William Klimke,Catarina Inês Mendes,S. Elizabeth Norred,Jonathon Parkinson,Samantha Sevilla,Mónica García Solache,Defne Surujon,Udana Torian,Vadim Zalunin,Benjamin R. Busby +22 more
TL;DR: An in-person hackathon to assist with developing cloud-based methods to reduce reliance on local computational infrastructure and can be augmented and built upon by the research community to aid in the rapid identification of microbial virulence factors.